Factors influencing the adsorption of Lutetium-177 on hydroxyapatite

A. A. Keeling, Andrew T M Vaughan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The in vitro adsorption of the osteotropic radioisotope 177Lu to hydroxyapatite was investigated. Adsorption was inhibited at low pH in the presence of a chelating acid (citrate) but not by acetate. The inhibition was caused by chelation of the Lu ion rather than acidity or solubilisation of the solid matrix, which also occurred under these conditions. Adsorption was not inhibited by Ca2+. The presence of chelating acids is predicted to be more important than low pH alone in inhibiting distribution in bone mineral in vivo.

Original languageEnglish (US)
Pages (from-to)489-492
Number of pages4
JournalNuclear Medicine and Biology
Volume15
Issue number5
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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