Factors influencing the adsorption of Lutetium-177 on hydroxyapatite

A. A. Keeling; Andrew T M Vaughan

Factors influencing the adsorption of Lutetium-177 on hydroxyapatite

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro adsorption of the osteotropic radioisotope ¹⁷⁷Lu to hydroxyapatite was investigated. Adsorption was inhibited at low pH in the presence of a chelating acid (citrate) but not by acetate. The inhibition was caused by chelation of the Lu ion rather than acidity or solubilisation of the solid matrix, which also occurred under these conditions. Adsorption was not inhibited by Ca²⁺. The presence of chelating acids is predicted to be more important than low pH alone in inhibiting distribution in bone mineral in vivo.

Original language	English (US)
Pages (from-to)	489-492
Number of pages	4
Journal	Nuclear Medicine and Biology
Volume	15
Issue number	5
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Molecular Medicine
Radiology Nuclear Medicine and imaging

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title = "Factors influencing the adsorption of Lutetium-177 on hydroxyapatite",

abstract = "The in vitro adsorption of the osteotropic radioisotope 177Lu to hydroxyapatite was investigated. Adsorption was inhibited at low pH in the presence of a chelating acid (citrate) but not by acetate. The inhibition was caused by chelation of the Lu ion rather than acidity or solubilisation of the solid matrix, which also occurred under these conditions. Adsorption was not inhibited by Ca2+. The presence of chelating acids is predicted to be more important than low pH alone in inhibiting distribution in bone mineral in vivo.",

author = "Keeling, {A. A.} and Vaughan, {Andrew T M}",

year = "1988",

language = "English (US)",

volume = "15",

pages = "489--492",

journal = "Nuclear Medicine and Biology",

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N2 - The in vitro adsorption of the osteotropic radioisotope 177Lu to hydroxyapatite was investigated. Adsorption was inhibited at low pH in the presence of a chelating acid (citrate) but not by acetate. The inhibition was caused by chelation of the Lu ion rather than acidity or solubilisation of the solid matrix, which also occurred under these conditions. Adsorption was not inhibited by Ca2+. The presence of chelating acids is predicted to be more important than low pH alone in inhibiting distribution in bone mineral in vivo.

AB - The in vitro adsorption of the osteotropic radioisotope 177Lu to hydroxyapatite was investigated. Adsorption was inhibited at low pH in the presence of a chelating acid (citrate) but not by acetate. The inhibition was caused by chelation of the Lu ion rather than acidity or solubilisation of the solid matrix, which also occurred under these conditions. Adsorption was not inhibited by Ca2+. The presence of chelating acids is predicted to be more important than low pH alone in inhibiting distribution in bone mineral in vivo.

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