This study investigated the factors which are associated with the development of bacteremia in pediatric patients who were recipients of a permanent central line. Over an 18 month period the charts of all pediatric patients with positive blood cultures drawn through the new central line (within 45 days of placement) were reviewed. An age matched uninfected control group was selected. Variables examined included preoperative fever, neutropenia (acute neutrophil count <1000), BMI (bone marrow involvement by malignancy or immunodeficiency disorder), use of preoperative antibiotics, type and location of central line, and patient diagnosis. A case control analysis was performed and odds ratios were calculated and chi square analysis with Yates correction was performed. Over this time period the overall incidence of early catheter infection was 57 out of 475 (12%). Odds ratios indicated a several fold higher likelihood of early infection on patients with neutropenia (OR=5.2, p<0.01) and BMI (OR=3.3, p<0.01). Preoperative fever increased the likelihood of infection insignificantly (OR=2.8, p=0.11). None of the other variables showed a tendency toward an association with infection. In the infected catheter group, 8 patients died (3 due to infection and 5 due to the underlying disease), 16 catheters had to be removed, and 33 infections resolved with antibiotics. In conclusion, neutropenia, and BMI are associated with early central line infection in pediatric patients, 28% of these result in premature catheter removal.
|Original language||English (US)|
|Journal||Journal of Investigative Medicine|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)