Factors influencing changes in articular cartilage following hemiarthroplasty in sheep

Marjolein C H Van Der Meulen, Gary S. Beaupré, R. Lane Smith, Virginia L. Giddings, William A. Allen, Kyriacos A. Athanasiou, Chong Fang Zhu, Jay A. Mandell, Yong Song, Robert D. Poser, Stuart B. Goodman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This study examined the relationship between acetabular cartilage properties after hemiarthroplasty surgery and surgical variables including femoral head size and position. Nineteen sheep received unilateral hip arthroplasties and were euthanized one year post-operatively to harvest the femora and acetabula. Cartilage histology, biochemistry and material properties were determined from samples located in the superior load-bearing region. Femoral head size mismatch, leg length difference, anterior-posterior and medial-lateral offset and anteversion were measured. In the acetabulum, substantial cartilage degradation occurred with widespread fibrillation and significant changes in the biochemical and material properties compared to the intact contralateral joint. Regression analyses on the surgical variables explained 75-80% of the changes in tissue biochemistry but did not explain the material changes. Head size mismatch and leg length difference were the most significant contributors of the five variables examined and therefore may be critical to successful outcome in hemiarthroplasty.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalJournal of Orthopaedic Research
Volume20
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Hemiarthroplasty
Articular Cartilage
Cartilage
Sheep
Acetabulum
Thigh
Biochemistry
Leg
Weight-Bearing
Arthroplasty
Femur
Hip
Histology
Joints
Head
Regression Analysis

Keywords

  • Articular cartilage
  • Cartilage material properties
  • Hemiarthroplasty
  • Sheep cartilage biochemistry

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Van Der Meulen, M. C. H., Beaupré, G. S., Lane Smith, R., Giddings, V. L., Allen, W. A., Athanasiou, K. A., ... Goodman, S. B. (2002). Factors influencing changes in articular cartilage following hemiarthroplasty in sheep. Journal of Orthopaedic Research, 20(4), 669-675. https://doi.org/10.1016/S0736-0266(01)00182-6

Factors influencing changes in articular cartilage following hemiarthroplasty in sheep. / Van Der Meulen, Marjolein C H; Beaupré, Gary S.; Lane Smith, R.; Giddings, Virginia L.; Allen, William A.; Athanasiou, Kyriacos A.; Fang Zhu, Chong; Mandell, Jay A.; Song, Yong; Poser, Robert D.; Goodman, Stuart B.

In: Journal of Orthopaedic Research, Vol. 20, No. 4, 2002, p. 669-675.

Research output: Contribution to journalArticle

Van Der Meulen, MCH, Beaupré, GS, Lane Smith, R, Giddings, VL, Allen, WA, Athanasiou, KA, Fang Zhu, C, Mandell, JA, Song, Y, Poser, RD & Goodman, SB 2002, 'Factors influencing changes in articular cartilage following hemiarthroplasty in sheep', Journal of Orthopaedic Research, vol. 20, no. 4, pp. 669-675. https://doi.org/10.1016/S0736-0266(01)00182-6
Van Der Meulen MCH, Beaupré GS, Lane Smith R, Giddings VL, Allen WA, Athanasiou KA et al. Factors influencing changes in articular cartilage following hemiarthroplasty in sheep. Journal of Orthopaedic Research. 2002;20(4):669-675. https://doi.org/10.1016/S0736-0266(01)00182-6
Van Der Meulen, Marjolein C H ; Beaupré, Gary S. ; Lane Smith, R. ; Giddings, Virginia L. ; Allen, William A. ; Athanasiou, Kyriacos A. ; Fang Zhu, Chong ; Mandell, Jay A. ; Song, Yong ; Poser, Robert D. ; Goodman, Stuart B. / Factors influencing changes in articular cartilage following hemiarthroplasty in sheep. In: Journal of Orthopaedic Research. 2002 ; Vol. 20, No. 4. pp. 669-675.
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