Factors influencing changes in articular cartilage following hemiarthroplasty in sheep

Marjolein C H Van Der Meulen, Gary S. Beaupré, R. Lane Smith, Virginia L. Giddings, William A. Allen, Kyriacos A. Athanasiou, Chong Fang Zhu, Jay A. Mandell, Yong Song, Robert D. Poser, Stuart B. Goodman

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

This study examined the relationship between acetabular cartilage properties after hemiarthroplasty surgery and surgical variables including femoral head size and position. Nineteen sheep received unilateral hip arthroplasties and were euthanized one year post-operatively to harvest the femora and acetabula. Cartilage histology, biochemistry and material properties were determined from samples located in the superior load-bearing region. Femoral head size mismatch, leg length difference, anterior-posterior and medial-lateral offset and anteversion were measured. In the acetabulum, substantial cartilage degradation occurred with widespread fibrillation and significant changes in the biochemical and material properties compared to the intact contralateral joint. Regression analyses on the surgical variables explained 75-80% of the changes in tissue biochemistry but did not explain the material changes. Head size mismatch and leg length difference were the most significant contributors of the five variables examined and therefore may be critical to successful outcome in hemiarthroplasty.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalJournal of Orthopaedic Research
Volume20
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Articular cartilage
  • Cartilage material properties
  • Hemiarthroplasty
  • Sheep cartilage biochemistry

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Factors influencing changes in articular cartilage following hemiarthroplasty in sheep'. Together they form a unique fingerprint.

  • Cite this

    Van Der Meulen, M. C. H., Beaupré, G. S., Lane Smith, R., Giddings, V. L., Allen, W. A., Athanasiou, K. A., Fang Zhu, C., Mandell, J. A., Song, Y., Poser, R. D., & Goodman, S. B. (2002). Factors influencing changes in articular cartilage following hemiarthroplasty in sheep. Journal of Orthopaedic Research, 20(4), 669-675. https://doi.org/10.1016/S0736-0266(01)00182-6