Factors affecting visual field outcomes in the idiopathic intracranial hypertension treatment trial

NORDIC Idiopathic Intracranial Hypertension Study Group

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: To determine the prevalence of visual field (VF) performance failures (PF) and treatment failures (TFs), and identify factors associated with PFs in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Methods: A total of 165 participants from 38 sites with idiopathic intracranial hypertension (IIH) and mild visual loss were randomized to either acetazolamide-plus diet or placebo-plus diet. The IIHTT Visual Field Reading Center evaluated 2950 Swedish Interactive Threshold Algorithm Standard 24-2 VFs from the enrolled participants. A TF was defined when the participant's VF mean deviation (MD) worsened ≥2 to 3 dB from the average baseline MD (range of -2 to -7 dB) with a second retest confirming the visual deterioration. A PF was determined when the participant's: 1) VF results met TF criteria but were not confirmed on retest, 2) deterioration was confirmed on retest but the IIHTT Adjudication Committee concluded a TF was clinically unlikely. Results: TF was detected in 7/165 (4%) of the participants and PF was detected in 35/165 (21%) of the participants on at least 1 examination. Four of the 35 PFs were adjudicated for TF, however based on clinical review by the adjudication committee and a third retest, they were judged as PFs. Of the 2,950 total IIHTT VF examinations, 2.7% met PF criteria. Conclusions: PF was confirmed in 21% of subjects and in 2.7% of the total number of VF examinations and was reversible on repeat testing. We recommend retesting when perimetric worsening occurs in otherwise clinically stable or improving IIH patients.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalJournal of Neuro-Ophthalmology
Volume36
Issue number1
DOIs
StatePublished - 2016

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Pseudotumor Cerebri
Visual Fields
Treatment Failure
Therapeutics
Diet
Acetazolamide
Advisory Committees
Reading
Placebos

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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Factors affecting visual field outcomes in the idiopathic intracranial hypertension treatment trial. / NORDIC Idiopathic Intracranial Hypertension Study Group.

In: Journal of Neuro-Ophthalmology, Vol. 36, No. 1, 2016, p. 6-12.

Research output: Contribution to journalArticle

NORDIC Idiopathic Intracranial Hypertension Study Group. / Factors affecting visual field outcomes in the idiopathic intracranial hypertension treatment trial. In: Journal of Neuro-Ophthalmology. 2016 ; Vol. 36, No. 1. pp. 6-12.
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abstract = "Background: To determine the prevalence of visual field (VF) performance failures (PF) and treatment failures (TFs), and identify factors associated with PFs in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Methods: A total of 165 participants from 38 sites with idiopathic intracranial hypertension (IIH) and mild visual loss were randomized to either acetazolamide-plus diet or placebo-plus diet. The IIHTT Visual Field Reading Center evaluated 2950 Swedish Interactive Threshold Algorithm Standard 24-2 VFs from the enrolled participants. A TF was defined when the participant's VF mean deviation (MD) worsened ≥2 to 3 dB from the average baseline MD (range of -2 to -7 dB) with a second retest confirming the visual deterioration. A PF was determined when the participant's: 1) VF results met TF criteria but were not confirmed on retest, 2) deterioration was confirmed on retest but the IIHTT Adjudication Committee concluded a TF was clinically unlikely. Results: TF was detected in 7/165 (4{\%}) of the participants and PF was detected in 35/165 (21{\%}) of the participants on at least 1 examination. Four of the 35 PFs were adjudicated for TF, however based on clinical review by the adjudication committee and a third retest, they were judged as PFs. Of the 2,950 total IIHTT VF examinations, 2.7{\%} met PF criteria. Conclusions: PF was confirmed in 21{\%} of subjects and in 2.7{\%} of the total number of VF examinations and was reversible on repeat testing. We recommend retesting when perimetric worsening occurs in otherwise clinically stable or improving IIH patients.",
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