Facilitation of kindling in adult rats following neonatal exposure to lindane

Timothy E Albertson; R. M. Joy; L. G. Stark

doi:10.1016/0165-3806(85)90151-8

Facilitation of kindling in adult rats following neonatal exposure to lindane

Timothy E Albertson, R. M. Joy, L. G. Stark

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 ± 0.5 days) than control groups (11.2 + 0.5 days). Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. These findings demonstrate that high exposures of lindane during development can lead to enduring changes in the nervous system that facilitate adult kindling.

Original language	English (US)
Pages (from-to)	263-266
Number of pages	4
Journal	Developmental Brain Research
Volume	17
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-3806(85)90151-8
State	Published - 1985

Keywords

amygdala
gamma-hexachlorocyclohexane
kindling
lindane
neonatal exposure

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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abstract = "Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 ± 0.5 days) than control groups (11.2 + 0.5 days). Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. These findings demonstrate that high exposures of lindane during development can lead to enduring changes in the nervous system that facilitate adult kindling.",

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T1 - Facilitation of kindling in adult rats following neonatal exposure to lindane

AU - Albertson, Timothy E

AU - Joy, R. M.

AU - Stark, L. G.

PY - 1985

Y1 - 1985

N2 - Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 ± 0.5 days) than control groups (11.2 + 0.5 days). Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. These findings demonstrate that high exposures of lindane during development can lead to enduring changes in the nervous system that facilitate adult kindling.

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KW - amygdala

KW - gamma-hexachlorocyclohexane

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Facilitation of kindling in adult rats following neonatal exposure to lindane

Abstract

Keywords

ASJC Scopus subject areas

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