Abstract
Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 ± 0.5 days) than control groups (11.2 + 0.5 days). Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. These findings demonstrate that high exposures of lindane during development can lead to enduring changes in the nervous system that facilitate adult kindling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 263-266 |
| Number of pages | 4 |
| Journal | Developmental Brain Research |
| Volume | 17 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 1985 |
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Keywords
- amygdala
- gamma-hexachlorocyclohexane
- kindling
- lindane
- neonatal exposure
ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Facilitation of kindling in adult rats following neonatal exposure to lindane. / Albertson, Timothy E; Joy, R. M.; Stark, L. G.
In: Developmental Brain Research, Vol. 17, No. 1-2, 1985, p. 263-266.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Facilitation of kindling in adult rats following neonatal exposure to lindane
AU - Albertson, Timothy E
AU - Joy, R. M.
AU - Stark, L. G.
PY - 1985
Y1 - 1985
N2 - Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 ± 0.5 days) than control groups (11.2 + 0.5 days). Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. These findings demonstrate that high exposures of lindane during development can lead to enduring changes in the nervous system that facilitate adult kindling.
AB - Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 ± 0.5 days) than control groups (11.2 + 0.5 days). Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. These findings demonstrate that high exposures of lindane during development can lead to enduring changes in the nervous system that facilitate adult kindling.
KW - amygdala
KW - gamma-hexachlorocyclohexane
KW - kindling
KW - lindane
KW - neonatal exposure
UR - http://www.scopus.com/inward/record.url?scp=0021960196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021960196&partnerID=8YFLogxK
U2 - 10.1016/0165-3806(85)90151-8
DO - 10.1016/0165-3806(85)90151-8
M3 - Article
C2 - 2580601
AN - SCOPUS:0021960196
VL - 17
SP - 263
EP - 266
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 1-2
ER -