Facilitation by strychnine of reflex walking in spinal dogs

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26 Scopus citations

Abstract

Results of previous studies have indicated that the spinal dog is incapable of reflex walking. In the present experiment subconvulsive doses of strychnine sulfate were given to non-walking spinal dogs and within a few minutes these animals displayed reflex walking. Two spinal dogs capable of moderate reflex walking before strychnine administration greatly improved their walking performance following administration of the drug. Since strychnine is believed to suppress postsynaptic inhibition, these observations suggest that the facilitation of reflex walking is due to a reduction of tonic intraspinal inhibition which is otherwise strong enough to prevent the occurrence of reflex walking in most spinal dogs.

Original languageEnglish (US)
Pages (from-to)627-628
Number of pages2
JournalPhysiology and Behavior
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1971

Keywords

  • Locomotor behavior
  • Reflexes
  • Spinal cord
  • Strychnine

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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