Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions

Youssef El Aziz, Nazia Mehrban, Peter G. Taylor, Martin A. Birchall, James Bowen, Alan R. Bassindale, Mateusz B. Pitak, Simon J. Coles

Research output: Contribution to journalArticle

2 Scopus citations


A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield (82-90%). The X-ray crystal structure revealed intra- and intermolecular hydrogen bonding between the amide groups of the arms. Hybrid biomaterials were synthesised in nearly quantitative yields via a click reaction with (i) azido-N-Fmoc-norleucine and (ii) 3′-azido-3′-deoxythymidine.

Original languageEnglish (US)
Pages (from-to)37474-37477
Number of pages4
JournalRSC Advances
Issue number59
StatePublished - 2017
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    El Aziz, Y., Mehrban, N., Taylor, P. G., Birchall, M. A., Bowen, J., Bassindale, A. R., Pitak, M. B., & Coles, S. J. (2017). Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions. RSC Advances, 7(59), 37474-37477. https://doi.org/10.1039/c7ra07915j