Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions

Youssef El Aziz, Nazia Mehrban, Peter G. Taylor, Martin A. Birchall, James Bowen, Alan R. Bassindale, Mateusz B. Pitak, Simon J. Coles

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield (82-90%). The X-ray crystal structure revealed intra- and intermolecular hydrogen bonding between the amide groups of the arms. Hybrid biomaterials were synthesised in nearly quantitative yields via a click reaction with (i) azido-N-Fmoc-norleucine and (ii) 3′-azido-3′-deoxythymidine.

Original languageEnglish (US)
Pages (from-to)37474-37477
Number of pages4
JournalRSC Advances
Volume7
Issue number59
DOIs
StatePublished - 2017
Externally publishedYes

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Norleucine
Alkynes
Zidovudine
Biocompatible Materials
Biomolecules
Amides
Biomaterials
Hydrogen bonds
Crystal structure
X rays

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

El Aziz, Y., Mehrban, N., Taylor, P. G., Birchall, M. A., Bowen, J., Bassindale, A. R., ... Coles, S. J. (2017). Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions. RSC Advances, 7(59), 37474-37477. https://doi.org/10.1039/c7ra07915j

Facile synthesis of novel hybrid POSS biomolecules : Via "click" reactions. / El Aziz, Youssef; Mehrban, Nazia; Taylor, Peter G.; Birchall, Martin A.; Bowen, James; Bassindale, Alan R.; Pitak, Mateusz B.; Coles, Simon J.

In: RSC Advances, Vol. 7, No. 59, 2017, p. 37474-37477.

Research output: Contribution to journalArticle

El Aziz, Y, Mehrban, N, Taylor, PG, Birchall, MA, Bowen, J, Bassindale, AR, Pitak, MB & Coles, SJ 2017, 'Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions', RSC Advances, vol. 7, no. 59, pp. 37474-37477. https://doi.org/10.1039/c7ra07915j
El Aziz Y, Mehrban N, Taylor PG, Birchall MA, Bowen J, Bassindale AR et al. Facile synthesis of novel hybrid POSS biomolecules: Via "click" reactions. RSC Advances. 2017;7(59):37474-37477. https://doi.org/10.1039/c7ra07915j
El Aziz, Youssef ; Mehrban, Nazia ; Taylor, Peter G. ; Birchall, Martin A. ; Bowen, James ; Bassindale, Alan R. ; Pitak, Mateusz B. ; Coles, Simon J. / Facile synthesis of novel hybrid POSS biomolecules : Via "click" reactions. In: RSC Advances. 2017 ; Vol. 7, No. 59. pp. 37474-37477.
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