Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation

Nianhuan Yao, Gabriel Fung, Hamed Malekan, Long Ye, Mark J. Kurth, Kit Lam

Research output: Contribution to journalArticle

8 Scopus citations


The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl4, BF3·Et 2O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides.

Original languageEnglish (US)
Pages (from-to)2277-2281
Number of pages5
JournalCarbohydrate Research
Issue number15
StatePublished - Oct 13 2010



  • Fmoc amino acids
  • Glycosylation
  • Microwave irradiation

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

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