Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation

Nianhuan Yao, Gabriel Fung, Hamed Malekan, Long Ye, Mark J. Kurth, Kit Lam

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl4, BF3·Et 2O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides.

Original languageEnglish (US)
Pages (from-to)2277-2281
Number of pages5
JournalCarbohydrate Research
Volume345
Issue number15
DOIs
StatePublished - Oct 13 2010

Fingerprint

Microwave irradiation
Microwaves
Amino Acids
Lewis Acids
Glycopeptides
Monosaccharides
Disaccharides
stannic chloride

Keywords

  • Fmoc amino acids
  • Glycosylation
  • Microwave irradiation

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation. / Yao, Nianhuan; Fung, Gabriel; Malekan, Hamed; Ye, Long; Kurth, Mark J.; Lam, Kit.

In: Carbohydrate Research, Vol. 345, No. 15, 13.10.2010, p. 2277-2281.

Research output: Contribution to journalArticle

Yao, Nianhuan ; Fung, Gabriel ; Malekan, Hamed ; Ye, Long ; Kurth, Mark J. ; Lam, Kit. / Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation. In: Carbohydrate Research. 2010 ; Vol. 345, No. 15. pp. 2277-2281.
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