Facile Syntheses of Novel Benzo-1,3-dioxolo-, Benzothiazolo-, Pyrido-, and Quinolino-fused 5 H -Benzo[ d ]-pyrazolo[5,1-b ][1,3]-oxazines and 1 H -Pyrazoles

Belem Avila, Danielle M. Solano, Makhluf J. Haddadin, Mark J. Kurth

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A number of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles were synthesized utilizing an easy and effective N,N-bond forming heterocyclization reaction. In so doing, the substrate scope of this heterocyclization reaction, which starts with o-nitroheterocyclic aldehydes, was expanded to provide several unique heterocyclic compounds for biological screening. This work further demonstrates the versatility of this simple, base-mediated, one-pot heterocyclization method in the construction of novel heterocycles.(Figure Presented)

Original languageEnglish (US)
Pages (from-to)1060-1063
Number of pages4
JournalOrganic Letters
Volume13
Issue number5
DOIs
StatePublished - Mar 4 2011

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Oxazines
Pyrazoles
Heterocyclic Compounds
Aldehydes
Screening
heterocyclic compounds
Substrates
versatility
synthesis
aldehydes
screening
oxazine 1

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Facile Syntheses of Novel Benzo-1,3-dioxolo-, Benzothiazolo-, Pyrido-, and Quinolino-fused 5 H -Benzo[ d ]-pyrazolo[5,1-b ][1,3]-oxazines and 1 H -Pyrazoles. / Avila, Belem; Solano, Danielle M.; Haddadin, Makhluf J.; Kurth, Mark J.

In: Organic Letters, Vol. 13, No. 5, 04.03.2011, p. 1060-1063.

Research output: Contribution to journalArticle

Avila, Belem ; Solano, Danielle M. ; Haddadin, Makhluf J. ; Kurth, Mark J. / Facile Syntheses of Novel Benzo-1,3-dioxolo-, Benzothiazolo-, Pyrido-, and Quinolino-fused 5 H -Benzo[ d ]-pyrazolo[5,1-b ][1,3]-oxazines and 1 H -Pyrazoles. In: Organic Letters. 2011 ; Vol. 13, No. 5. pp. 1060-1063.
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