Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions

Huy H. Nguyen, Teresa A. Palazzo, Mark J. Kurth

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

An operationally simple, one-pot multicomponent reaction has been developed for the assembly of 9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4] diazepines adorned with three diversification points via an atom-economical transformation incorporating α-diketones, o-azidobenzaldehydes, propargylic amines, and ammonium acetate. This process involves tandem InCl 3-catalyzed cyclocondensation and intramolecular azide-alkyne 1,3-dipolar cycloaddition reactions; optimization data, substrate scope, and mechanistic insights are discussed.

Original languageEnglish (US)
Pages (from-to)4492-4495
Number of pages4
JournalOrganic Letters
Volume15
Issue number17
DOIs
StatePublished - Sep 6 2013

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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