Abstract
A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5098-5101 |
| Number of pages | 4 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 13 |
| Issue number | 18 |
| DOIs | |
| State | Published - May 14 2015 |
Fingerprint
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry
Cite this
Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide. / Wu, Baolin; Wei, Na; Thon, Vireak; Wei, Mohui; Yu, Zaikuan; Xu, Yongmei; Chen, Xi; Liu, Jian; Wang, Peng George; Li, Tiehai.
In: Organic and Biomolecular Chemistry, Vol. 13, No. 18, 14.05.2015, p. 5098-5101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide
AU - Wu, Baolin
AU - Wei, Na
AU - Thon, Vireak
AU - Wei, Mohui
AU - Yu, Zaikuan
AU - Xu, Yongmei
AU - Chen, Xi
AU - Liu, Jian
AU - Wang, Peng George
AU - Li, Tiehai
PY - 2015/5/14
Y1 - 2015/5/14
N2 - A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.
AB - A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=84928901912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928901912&partnerID=8YFLogxK
U2 - 10.1039/c5ob00462d
DO - 10.1039/c5ob00462d
M3 - Article
C2 - 25858766
AN - SCOPUS:84928901912
VL - 13
SP - 5098
EP - 5101
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 18
ER -