Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide

Baolin Wu, Na Wei, Vireak Thon, Mohui Wei, Zaikuan Yu, Yongmei Xu, Xi Chen, Jian Liu, Peng George Wang, Tiehai Li

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.

Original languageEnglish (US)
Pages (from-to)5098-5101
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number18
DOIs
StatePublished - May 14 2015

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Wu, B., Wei, N., Thon, V., Wei, M., Yu, Z., Xu, Y., Chen, X., Liu, J., Wang, P. G., & Li, T. (2015). Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide. Organic and Biomolecular Chemistry, 13(18), 5098-5101. https://doi.org/10.1039/c5ob00462d