Abstract
A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.
Original language | English (US) |
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Pages (from-to) | 5098-5101 |
Number of pages | 4 |
Journal | Organic and Biomolecular Chemistry |
Volume | 13 |
Issue number | 18 |
DOIs | |
State | Published - May 14 2015 |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry