Facet Joints of the Spine: Structure-Function Relationships, Problems and Treatments, and the Potential for Regeneration

Siobhan A. O'Leary, Nikolaos K. Paschos, Jarrett M. Link, Eric Otto Klineberg, Jerry C. Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The zygapophysial joint, a diarthrodial joint commonly referred to as the facet joint, plays a pivotal role in back pain, a condition that has been a leading cause of global disability since 1990. Along with the intervertebral disc, the facet joint supports spinal motion and aids in spinal stability. Highly susceptible to early development of osteoarthritis, the facet is responsible for a significant amount of pain in the low-back, mid-back, and neck regions. Current noninvasive treatments cannot offer long-term pain relief, while invasive treatments can relieve pain but fail to preserve joint functionality. This review presents an overview of the facet in terms of its anatomy, functional properties, problems, and current management strategies. Furthermore, this review introduces the potential for regeneration of the facet and particular engineering strategies that could be employed as a long-term treatment.

Original languageEnglish (US)
Pages (from-to)145-170
Number of pages26
JournalAnnual Review of Biomedical Engineering
Volume20
DOIs
StatePublished - Jun 4 2018

Fingerprint

Zygapophyseal Joint
Regeneration
Spine
Joints
Pain
Intervertebral Disc
Back Pain
Low Back Pain
Osteoarthritis
Anatomy
Neck
Therapeutics

Keywords

  • biomechanics
  • facet joint
  • osteoarthritis
  • spinal stenosis
  • tissue engineering
  • zygapophysial joint

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Facet Joints of the Spine : Structure-Function Relationships, Problems and Treatments, and the Potential for Regeneration. / O'Leary, Siobhan A.; Paschos, Nikolaos K.; Link, Jarrett M.; Klineberg, Eric Otto; Hu, Jerry C.; Athanasiou, Kyriacos A.

In: Annual Review of Biomedical Engineering, Vol. 20, 04.06.2018, p. 145-170.

Research output: Contribution to journalReview article

O'Leary, Siobhan A. ; Paschos, Nikolaos K. ; Link, Jarrett M. ; Klineberg, Eric Otto ; Hu, Jerry C. ; Athanasiou, Kyriacos A. / Facet Joints of the Spine : Structure-Function Relationships, Problems and Treatments, and the Potential for Regeneration. In: Annual Review of Biomedical Engineering. 2018 ; Vol. 20. pp. 145-170.
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