Fabrication of silicon-based nanoparticles for biological imaging

Xiaoming Zhang, Doinita Neiner, Shizhong Wang, Angelique Y. Louie, Susan M. Kauzlarich

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


Fluorescent silicon nanomaterials have initiated great interest for their potential biological applications. In this paper, we report the synthesis of water-soluble, luminescent silicon nanoparticles with high quantum yield. The surfaces of the Si nanoparticles were capped by hydrophobic or hydrophilic organic molecules that passivate and protect the silicon particles from oxidation. The as-synthesized silicon nanoparticles displayed strong photoluminescence in the blue region of the visible spectrum. The attached organic molecules conveyed both water solubility and high stability, and coating had little adverse effect on the optical properties of nanoparticles. These results have major implications towards using colloidal silicon nanoparticles effectively in biological fluorescence imaging.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2007
EventColloidal Quantum Dots for Biomedical Applications II - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007


OtherColloidal Quantum Dots for Biomedical Applications II
Country/TerritoryUnited States
CitySan Jose, CA


  • Fluorescence imaging
  • Photo luminescence
  • Silicon
  • Water-soluble

ASJC Scopus subject areas

  • Engineering(all)


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