F-19 MR imaging of glucose metabolism in the rabbit

T. Nakada, Ingrid Kwee, B. V. Griffey, R. H. Griffey

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Noninvasive metabolic magnetic resonance (MR) imaging reflecting glucose metabolism in the aldose-reductase-sorbitol (ARS) pathway was performed in the rabbit head; after administration of the fluorinated glucose analogue 3-fluoro-3-deoxy-D-glucose (3FD-glucose), fluorine-19 images were generated. Images of 3FD-glucose showed significant 3FD-glucose uptake by adipose tissue, indicating its buffering effects in case of excess loads of glucose. Images of 3-fluoro-3-deoxy-D-sorbitol (3FD-sorbitol) demonstrated the spatial distribution of aldose reductase activities and significant sorbitol accumulation in the lens. Images of 3-fluoro-3-deoxy-D-fructose (3FD-fructose) showed preferential uptake of fructose by muscle tissue. The extremely low toxicity of 3FD-glucose indicates promise for its clinical application in metabolic imaging.

Original languageEnglish (US)
Pages (from-to)823-825
Number of pages3
JournalRadiology
Volume168
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Nakada, T., Kwee, I., Griffey, B. V., & Griffey, R. H. (1988). F-19 MR imaging of glucose metabolism in the rabbit. Radiology, 168(3), 823-825.