Abstract
Noninvasive metabolic magnetic resonance (MR) imaging reflecting glucose metabolism in the aldose-reductase-sorbitol (ARS) pathway was performed in the rabbit head; after administration of the fluorinated glucose analogue 3-fluoro-3-deoxy-D-glucose (3FD-glucose), fluorine-19 images were generated. Images of 3FD-glucose showed significant 3FD-glucose uptake by adipose tissue, indicating its buffering effects in case of excess loads of glucose. Images of 3-fluoro-3-deoxy-D-sorbitol (3FD-sorbitol) demonstrated the spatial distribution of aldose reductase activities and significant sorbitol accumulation in the lens. Images of 3-fluoro-3-deoxy-D-fructose (3FD-fructose) showed preferential uptake of fructose by muscle tissue. The extremely low toxicity of 3FD-glucose indicates promise for its clinical application in metabolic imaging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 823-825 |
| Number of pages | 3 |
| Journal | Radiology |
| Volume | 168 |
| Issue number | 3 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Radiological and Ultrasound Technology
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F-19 MR imaging of glucose metabolism in the rabbit. / Nakada, T.; Kwee, Ingrid; Griffey, B. V.; Griffey, R. H.
In: Radiology, Vol. 168, No. 3, 1988, p. 823-825.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - F-19 MR imaging of glucose metabolism in the rabbit
AU - Nakada, T.
AU - Kwee, Ingrid
AU - Griffey, B. V.
AU - Griffey, R. H.
PY - 1988
Y1 - 1988
N2 - Noninvasive metabolic magnetic resonance (MR) imaging reflecting glucose metabolism in the aldose-reductase-sorbitol (ARS) pathway was performed in the rabbit head; after administration of the fluorinated glucose analogue 3-fluoro-3-deoxy-D-glucose (3FD-glucose), fluorine-19 images were generated. Images of 3FD-glucose showed significant 3FD-glucose uptake by adipose tissue, indicating its buffering effects in case of excess loads of glucose. Images of 3-fluoro-3-deoxy-D-sorbitol (3FD-sorbitol) demonstrated the spatial distribution of aldose reductase activities and significant sorbitol accumulation in the lens. Images of 3-fluoro-3-deoxy-D-fructose (3FD-fructose) showed preferential uptake of fructose by muscle tissue. The extremely low toxicity of 3FD-glucose indicates promise for its clinical application in metabolic imaging.
AB - Noninvasive metabolic magnetic resonance (MR) imaging reflecting glucose metabolism in the aldose-reductase-sorbitol (ARS) pathway was performed in the rabbit head; after administration of the fluorinated glucose analogue 3-fluoro-3-deoxy-D-glucose (3FD-glucose), fluorine-19 images were generated. Images of 3FD-glucose showed significant 3FD-glucose uptake by adipose tissue, indicating its buffering effects in case of excess loads of glucose. Images of 3-fluoro-3-deoxy-D-sorbitol (3FD-sorbitol) demonstrated the spatial distribution of aldose reductase activities and significant sorbitol accumulation in the lens. Images of 3-fluoro-3-deoxy-D-fructose (3FD-fructose) showed preferential uptake of fructose by muscle tissue. The extremely low toxicity of 3FD-glucose indicates promise for its clinical application in metabolic imaging.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023792623&partnerID=8YFLogxK
M3 - Article
C2 - 3136509
AN - SCOPUS:0023792623
VL - 168
SP - 823
EP - 825
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -