Global climate change (GCC) is a major threat to global biodiversity that will put many species at risk. Understanding species responses to combined effects between GCC and increased pesticide use requires an interdisciplinary perspective, combining molecular, physiological, and ecological approaches. A recent ?Letter to the Editor? by Stewart (Stewart, A. J. Ecotoxicology: It?s Time for a Hard Re-Look. Environ. Toxicol. Chem. 2018, 37, 9?10) highlighted the need to re-evaluate the way in which ecotoxicological studies are conducted, indicating that the next generation of ecotoxicologists will need to reshape and advance the feld to incorporate the following concerns: rapidly changing environmental conditions associated with GCC, the current and rapidly developing suite of tools and approaches available to determine toxicological effects, and the many computational advances that can be used toward predicting chemicals? distribution and fate, as well as modeling physiological and population level effects. This chapter further stresses the importance of this reevaluation toward developing a stronger, more effective, collaborative, and multidisciplinary feld to provide quantitative and qualitative data that can adequately be used in pesticide regulation. Further integration and collaboration among researchers, regulators, environmental managers, and stakeholders are needed nationally and globally to adequately address the ever-changing and predicted increased use of pesticides, particularly in light of GCC.