Extremity Soft Tissue Sarcoma: Tailoring Resection to Histologic Subtype

Matthew G. Cable, R Randall

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Soft tissue sarcomas comprise tumors originating from mesenchymal or connective tissue. Histologic grade is integral to prognosis. Because sarcoma management is multimodal, histologic subtype should inform optimum treatment. Appropriate biopsy and communication between surgeon and pathologist can help ensure a correct diagnosis. Treatment often involves surgical excision with wide margins and adjuvant radiotherapy. There is no consensus on what constitutes an adequate margin for histologic subtypes. An appreciation of how histology corresponds with tumor biology and surgical anatomic constraints is needed for management of this disease. Even with the surgical goal of wide resection being obtained, many patients do not outlive their disease.

Original languageEnglish (US)
Pages (from-to)677-695
Number of pages19
JournalSurgical Oncology Clinics of North America
Issue number4
StatePublished - Oct 1 2016
Externally publishedYes


  • Extremity sarcoma
  • Histologic grade
  • Representative biopsy
  • Resection margin
  • Sarcoma subtypes

ASJC Scopus subject areas

  • Surgery
  • Oncology


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