Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells

Sonja J. Pyott, Elisabeth Glowatzki, James Trimmer, Richard W. Aldrich

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Auditory hair cells from nonmammalian vertebrates are electrically tuned to specific sound frequencies primarily by the interactions of voltage-gated calcium channels and calcium-activated potassium (BK) channels colocalized at synaptic active zones. Mammalian inner hair cells are not electrically tuned and, yet, BK channels are also thought to reside at active zones. Using patch-clamp recordings and immunofluorescence, we characterized BK channel expression in mouse inner hair cells. Unexpectedly, these channels have inactivating currents and are clustered near the apex of the cell away from synaptic sites near the base. These results indicate a novel function of BK channels in mammalian inner hair cells and provide a framework for future research.

Original languageEnglish (US)
Pages (from-to)9469-9474
Number of pages6
JournalJournal of Neuroscience
Volume24
Issue number43
DOIs
StatePublished - Oct 27 2004

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Inner Auditory Hair Cells
Large-Conductance Calcium-Activated Potassium Channels
Calcium-Activated Potassium Channels
Auditory Hair Cells
Calcium Channels
Fluorescent Antibody Technique
Vertebrates

Keywords

  • Cochlea
  • Hearing
  • K1.1
  • KCNMA1
  • Slo
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells. / Pyott, Sonja J.; Glowatzki, Elisabeth; Trimmer, James; Aldrich, Richard W.

In: Journal of Neuroscience, Vol. 24, No. 43, 27.10.2004, p. 9469-9474.

Research output: Contribution to journalArticle

Pyott, Sonja J. ; Glowatzki, Elisabeth ; Trimmer, James ; Aldrich, Richard W. / Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells. In: Journal of Neuroscience. 2004 ; Vol. 24, No. 43. pp. 9469-9474.
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