Extracellular matrix enriched spheroids for enhanced survival and differentiation of mesenchymal stem cells

Tomas Gonzalez-Fernandez, Andrew T. Keown, Alejandro J. Tenorio, Jonathan K Leach

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The recapitulation of the cellular niche is of special importance to promote stem cell survival and phenotype specification following transplantation. The formation of mesenchymal stem cells (MSCs) into three-dimensional spheroids enhances their survival, trophic factor secretion, and tissue-forming potential compared to monodisperse cells (1). Moreover, cell-secreted ECM represents a more complex platform to recapitulate the cues to guide stem cell fate versus individual matrix proteins or functional motifs (2). We previously demonstrated that MSC-secreted ECM increased progenitor cell osteogenic differentiation of diverse origins and donor populations (2). Therefore, we hypothesized that the formation of MSC spheroids enriched with cell-secreted ECM would enhance MSC viability, proliferation and differentiation potential.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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