Abstract
Objective: This study aimed to externally validate a nomogram for predicting overall survival of women with uterine cancer in an African American population. Methods: After the institutional review board approval, data from the uterine cancer database from 2 major teaching hospitals in Brooklyn, NY, were analyzed. The predicted survival for each patient was calculated with the use of the nonogram; the datawere clustered in deciles and compared with the observed survival data. Results: High incidence of aggressive histologic types (22% carcinosarcoma, 16% serous/clear cell), poorly differentiated (53% grade 3), and advanced stage (38% stage III or IV) tumors was found in our study population. The median follow-up for survivors was 52 months (range, 1Y274 months). The observed and predicted 3-year overall survival probabilities were significantly different (62.5% vs 72.6%, P < 0.001). Similarly, the observed 5-year overall survival probability was significantly lower than the predicted by the nomogram (55.5% vs 63.4%, P < 0.001). The discrepancy between predicted and observed survival was more pronounced in the midrisk groups. Conclusions: The nomogram is not an adequate tool to predict survival in the African American population with cancer of the uterine corpus. Race seems to be a significant, independent factor that affects survival and should be included in predictive models.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-90 |
| Number of pages | 6 |
| Journal | International Journal of Gynecological Cancer |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2014 |
| Externally published | Yes |
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Keywords
- African American race
- Nomogram
- Survival
- Uterine cancer
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Oncology
Cite this
External validation of a nomogram for predicting survival of women with uterine cancer in a cohort of african american patients. / Alagkiozidis, Ioannis; Wilson, Kirstie; Ruffner, Nichole D; Weedon, Jeremy; Serur, Eli; Economos, Katherine; Abulafia, Ovadia; Lee, Yi Chun; Salame, Ghadir.
In: International Journal of Gynecological Cancer, Vol. 24, No. 1, 01.2014, p. 85-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - External validation of a nomogram for predicting survival of women with uterine cancer in a cohort of african american patients
AU - Alagkiozidis, Ioannis
AU - Wilson, Kirstie
AU - Ruffner, Nichole D
AU - Weedon, Jeremy
AU - Serur, Eli
AU - Economos, Katherine
AU - Abulafia, Ovadia
AU - Lee, Yi Chun
AU - Salame, Ghadir
PY - 2014/1
Y1 - 2014/1
N2 - Objective: This study aimed to externally validate a nomogram for predicting overall survival of women with uterine cancer in an African American population. Methods: After the institutional review board approval, data from the uterine cancer database from 2 major teaching hospitals in Brooklyn, NY, were analyzed. The predicted survival for each patient was calculated with the use of the nonogram; the datawere clustered in deciles and compared with the observed survival data. Results: High incidence of aggressive histologic types (22% carcinosarcoma, 16% serous/clear cell), poorly differentiated (53% grade 3), and advanced stage (38% stage III or IV) tumors was found in our study population. The median follow-up for survivors was 52 months (range, 1Y274 months). The observed and predicted 3-year overall survival probabilities were significantly different (62.5% vs 72.6%, P < 0.001). Similarly, the observed 5-year overall survival probability was significantly lower than the predicted by the nomogram (55.5% vs 63.4%, P < 0.001). The discrepancy between predicted and observed survival was more pronounced in the midrisk groups. Conclusions: The nomogram is not an adequate tool to predict survival in the African American population with cancer of the uterine corpus. Race seems to be a significant, independent factor that affects survival and should be included in predictive models.
AB - Objective: This study aimed to externally validate a nomogram for predicting overall survival of women with uterine cancer in an African American population. Methods: After the institutional review board approval, data from the uterine cancer database from 2 major teaching hospitals in Brooklyn, NY, were analyzed. The predicted survival for each patient was calculated with the use of the nonogram; the datawere clustered in deciles and compared with the observed survival data. Results: High incidence of aggressive histologic types (22% carcinosarcoma, 16% serous/clear cell), poorly differentiated (53% grade 3), and advanced stage (38% stage III or IV) tumors was found in our study population. The median follow-up for survivors was 52 months (range, 1Y274 months). The observed and predicted 3-year overall survival probabilities were significantly different (62.5% vs 72.6%, P < 0.001). Similarly, the observed 5-year overall survival probability was significantly lower than the predicted by the nomogram (55.5% vs 63.4%, P < 0.001). The discrepancy between predicted and observed survival was more pronounced in the midrisk groups. Conclusions: The nomogram is not an adequate tool to predict survival in the African American population with cancer of the uterine corpus. Race seems to be a significant, independent factor that affects survival and should be included in predictive models.
KW - African American race
KW - Nomogram
KW - Survival
KW - Uterine cancer
UR - http://www.scopus.com/inward/record.url?scp=84893667390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893667390&partnerID=8YFLogxK
U2 - 10.1097/IGC.0000000000000039
DO - 10.1097/IGC.0000000000000039
M3 - Article
C2 - 24362715
AN - SCOPUS:84893667390
VL - 24
SP - 85
EP - 90
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
SN - 1048-891X
IS - 1
ER -