Extensive incorporation of dietary δ-5,11,14 eicosatrienoate into the phosphatidylinositol pool

Alvin Berger, J. Bruce German

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The acyl composition of phosphatidylinositol (PI) is remarkably resistant to dietary fatty acid modification. To investigate the basis of this selectivity, we have probed fatty acids lacking the usual methylene interrupted double bonds. When mice were fed Δ-5,11,14 20:3 as 3% of total lipid, this fatty acid, lacking the Δ-8 double bond essential for eicosanoid synthesis, replaced a significant quantity of 20:4(n - 6) in PI, but not PC and PE. By altering the acyl composition of PI, novel second messengers may be formed. This fatty acid structure thus provides a unique nutritional tool for investigating the basis of PI acyl specificity, and for determining the metabolic consequences of acyl alteration, in vivo.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1085
Issue number3
DOIs
StatePublished - Oct 1 1991

Keywords

  • (A. vulgaris)
  • (P. orientalis)
  • Fatty acid
  • Phosphatidylinositol
  • Phospholipid
  • Δ-5,11,14,17-Icosatetraenoate
  • Δ-5,11,14-Icosatrienoate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology

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