Extensive incorporation of dietary δ-5,11,14 eicosatrienoate into the phosphatidylinositol pool

Alvin Berger; J. Bruce German

doi:10.1016/0005-2760(91)90142-5

Extensive incorporation of dietary δ-5,11,14 eicosatrienoate into the phosphatidylinositol pool

Alvin Berger, J. Bruce German

Food Science & Technology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The acyl composition of phosphatidylinositol (PI) is remarkably resistant to dietary fatty acid modification. To investigate the basis of this selectivity, we have probed fatty acids lacking the usual methylene interrupted double bonds. When mice were fed Δ-5,11,14 20:3 as 3% of total lipid, this fatty acid, lacking the Δ-8 double bond essential for eicosanoid synthesis, replaced a significant quantity of 20:4(n - 6) in PI, but not PC and PE. By altering the acyl composition of PI, novel second messengers may be formed. This fatty acid structure thus provides a unique nutritional tool for investigating the basis of PI acyl specificity, and for determining the metabolic consequences of acyl alteration, in vivo.

Original language	English (US)
Pages (from-to)	371-376
Number of pages	6
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	1085
Issue number	3
DOIs	https://doi.org/10.1016/0005-2760(91)90142-5
State	Published - Oct 1 1991

Keywords

(A. vulgaris)
(P. orientalis)
Fatty acid
Phosphatidylinositol
Phospholipid
Δ-5,11,14,17-Icosatetraenoate
Δ-5,11,14-Icosatrienoate

ASJC Scopus subject areas

Biochemistry
Biophysics
Endocrinology

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title = "Extensive incorporation of dietary δ-5,11,14 eicosatrienoate into the phosphatidylinositol pool",

abstract = "The acyl composition of phosphatidylinositol (PI) is remarkably resistant to dietary fatty acid modification. To investigate the basis of this selectivity, we have probed fatty acids lacking the usual methylene interrupted double bonds. When mice were fed Δ-5,11,14 20:3 as 3% of total lipid, this fatty acid, lacking the Δ-8 double bond essential for eicosanoid synthesis, replaced a significant quantity of 20:4(n - 6) in PI, but not PC and PE. By altering the acyl composition of PI, novel second messengers may be formed. This fatty acid structure thus provides a unique nutritional tool for investigating the basis of PI acyl specificity, and for determining the metabolic consequences of acyl alteration, in vivo.",

keywords = "(A. vulgaris), (P. orientalis), Fatty acid, Phosphatidylinositol, Phospholipid, Δ-5,11,14,17-Icosatetraenoate, Δ-5,11,14-Icosatrienoate",

author = "Alvin Berger and {Bruce German}, J.",

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N2 - The acyl composition of phosphatidylinositol (PI) is remarkably resistant to dietary fatty acid modification. To investigate the basis of this selectivity, we have probed fatty acids lacking the usual methylene interrupted double bonds. When mice were fed Δ-5,11,14 20:3 as 3% of total lipid, this fatty acid, lacking the Δ-8 double bond essential for eicosanoid synthesis, replaced a significant quantity of 20:4(n - 6) in PI, but not PC and PE. By altering the acyl composition of PI, novel second messengers may be formed. This fatty acid structure thus provides a unique nutritional tool for investigating the basis of PI acyl specificity, and for determining the metabolic consequences of acyl alteration, in vivo.

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