Extending biochemical databases by metabolomic surveys

Oliver Fiehn, Dinesh K. Barupal, Tobias Kind

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Metabolomics can map the large metabolic diversity in species, organs, or cell types. In addition to gains in enzyme specificity, many enzymes have retained substrate and reaction promiscuity. Enzyme promiscuity and the large number of enzymes with unknown enzyme function may explain the presence of a plethora of unidentified compounds in metabolomic studies. Cataloguing the identity and differential abundance of all detectable metabolites in metabolomic repositories may detail which compounds and pathways contribute to vital biological functions. The current status in metabolic databases is reviewed concomitant with tools to map and visualize the metabolome.

Original languageEnglish (US)
Pages (from-to)23637-23643
Number of pages7
JournalJournal of Biological Chemistry
Volume286
Issue number27
DOIs
StatePublished - Jul 8 2011

Fingerprint

Metabolomics
Databases
Enzymes
Cataloging
Metabolome
Metabolites
Surveys and Questionnaires
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Extending biochemical databases by metabolomic surveys. / Fiehn, Oliver; Barupal, Dinesh K.; Kind, Tobias.

In: Journal of Biological Chemistry, Vol. 286, No. 27, 08.07.2011, p. 23637-23643.

Research output: Contribution to journalArticle

Fiehn, Oliver ; Barupal, Dinesh K. ; Kind, Tobias. / Extending biochemical databases by metabolomic surveys. In: Journal of Biological Chemistry. 2011 ; Vol. 286, No. 27. pp. 23637-23643.
@article{b3fcac29c52440d78123569d60128b55,
title = "Extending biochemical databases by metabolomic surveys",
abstract = "Metabolomics can map the large metabolic diversity in species, organs, or cell types. In addition to gains in enzyme specificity, many enzymes have retained substrate and reaction promiscuity. Enzyme promiscuity and the large number of enzymes with unknown enzyme function may explain the presence of a plethora of unidentified compounds in metabolomic studies. Cataloguing the identity and differential abundance of all detectable metabolites in metabolomic repositories may detail which compounds and pathways contribute to vital biological functions. The current status in metabolic databases is reviewed concomitant with tools to map and visualize the metabolome.",
author = "Oliver Fiehn and Barupal, {Dinesh K.} and Tobias Kind",
year = "2011",
month = "7",
day = "8",
doi = "10.1074/jbc.R110.173617",
language = "English (US)",
volume = "286",
pages = "23637--23643",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "27",

}

TY - JOUR

T1 - Extending biochemical databases by metabolomic surveys

AU - Fiehn, Oliver

AU - Barupal, Dinesh K.

AU - Kind, Tobias

PY - 2011/7/8

Y1 - 2011/7/8

N2 - Metabolomics can map the large metabolic diversity in species, organs, or cell types. In addition to gains in enzyme specificity, many enzymes have retained substrate and reaction promiscuity. Enzyme promiscuity and the large number of enzymes with unknown enzyme function may explain the presence of a plethora of unidentified compounds in metabolomic studies. Cataloguing the identity and differential abundance of all detectable metabolites in metabolomic repositories may detail which compounds and pathways contribute to vital biological functions. The current status in metabolic databases is reviewed concomitant with tools to map and visualize the metabolome.

AB - Metabolomics can map the large metabolic diversity in species, organs, or cell types. In addition to gains in enzyme specificity, many enzymes have retained substrate and reaction promiscuity. Enzyme promiscuity and the large number of enzymes with unknown enzyme function may explain the presence of a plethora of unidentified compounds in metabolomic studies. Cataloguing the identity and differential abundance of all detectable metabolites in metabolomic repositories may detail which compounds and pathways contribute to vital biological functions. The current status in metabolic databases is reviewed concomitant with tools to map and visualize the metabolome.

UR - http://www.scopus.com/inward/record.url?scp=79959898098&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959898098&partnerID=8YFLogxK

U2 - 10.1074/jbc.R110.173617

DO - 10.1074/jbc.R110.173617

M3 - Article

VL - 286

SP - 23637

EP - 23643

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 27

ER -