Extending biochemical databases by metabolomic surveys

Oliver Fiehn, Dinesh K. Barupal, Tobias Kind

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Metabolomics can map the large metabolic diversity in species, organs, or cell types. In addition to gains in enzyme specificity, many enzymes have retained substrate and reaction promiscuity. Enzyme promiscuity and the large number of enzymes with unknown enzyme function may explain the presence of a plethora of unidentified compounds in metabolomic studies. Cataloguing the identity and differential abundance of all detectable metabolites in metabolomic repositories may detail which compounds and pathways contribute to vital biological functions. The current status in metabolic databases is reviewed concomitant with tools to map and visualize the metabolome.

Original languageEnglish (US)
Pages (from-to)23637-23643
Number of pages7
JournalJournal of Biological Chemistry
Volume286
Issue number27
DOIs
StatePublished - Jul 8 2011

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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