Extended findings of brain metabolite normalization in MA-dependent subjects across sustained abstinence

A proton MRS study

Ruth Salo, Michael H. Buonocore, Martin H Leamon, Yutaka Natsuaki, Christy Waters, Charles D. Moore, Gantt P. Galloway, Thomas E Nordahl

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: The goal of the present study was to extend our previous findings on long-term methamphetamine (MA) use and drug abstinence on brain metabolite levels in an expanded group of MA-dependent individuals. Methods: Seventeen MA abusers with sustained drug abstinence (1-5 years), 30 MA abusers with short-term drug abstinence (1-6 months) and 24 non-substance using controls were studied using MR spectroscopy (MRS). MRS measures of NAA/Cr, Cho/Cr and Cho/NAA were obtained in the anterior cingulate cortex (ACC) and in the primary visual cortex (PVC). Results: ACC-Cho/NAA values were abnormally high in the short-term abstinent group compared to controls [. F(1,52) = 18.76, p< 0.0001]. No differences were observed between controls and the long-term abstinent group [. F(1,39) = 0.97, p= 0.97]. New evidence of lower ACC-NAA/Cr levels were observed in the short-term abstinent MA abusers compared to controls [. F(1,52) = 23.05, p< 0.0001] and long-term abstinent MA abusers [. F(1,45) = 7.06, p= 0.01]. No differences were observed between long-term abstinent MA abusers and controls [. F(1,39) = 0.48, p= 0.49]. Conclusions: The new findings of relative NAA/Cr normalization across periods of abstinence suggest that adaptive changes following cessation of MA abuse may be broader than initially thought. These changes may contribute to some degree of normalization of neuronal function in the ACC.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalDrug and Alcohol Dependence
Volume113
Issue number2-3
DOIs
StatePublished - Jan 15 2011

Fingerprint

Methamphetamine
Metabolites
Protons
Brain
Magnetic Resonance Spectroscopy
Spectroscopy
Gyrus Cinguli
Pharmaceutical Preparations
Visual Cortex

Keywords

  • Anterior cingulate cortex
  • Cho
  • Imaging
  • Methamphetamine
  • MRS
  • NAA

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Extended findings of brain metabolite normalization in MA-dependent subjects across sustained abstinence : A proton MRS study. / Salo, Ruth; Buonocore, Michael H.; Leamon, Martin H; Natsuaki, Yutaka; Waters, Christy; Moore, Charles D.; Galloway, Gantt P.; Nordahl, Thomas E.

In: Drug and Alcohol Dependence, Vol. 113, No. 2-3, 15.01.2011, p. 133-138.

Research output: Contribution to journalArticle

Salo, Ruth ; Buonocore, Michael H. ; Leamon, Martin H ; Natsuaki, Yutaka ; Waters, Christy ; Moore, Charles D. ; Galloway, Gantt P. ; Nordahl, Thomas E. / Extended findings of brain metabolite normalization in MA-dependent subjects across sustained abstinence : A proton MRS study. In: Drug and Alcohol Dependence. 2011 ; Vol. 113, No. 2-3. pp. 133-138.
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abstract = "Objective: The goal of the present study was to extend our previous findings on long-term methamphetamine (MA) use and drug abstinence on brain metabolite levels in an expanded group of MA-dependent individuals. Methods: Seventeen MA abusers with sustained drug abstinence (1-5 years), 30 MA abusers with short-term drug abstinence (1-6 months) and 24 non-substance using controls were studied using MR spectroscopy (MRS). MRS measures of NAA/Cr, Cho/Cr and Cho/NAA were obtained in the anterior cingulate cortex (ACC) and in the primary visual cortex (PVC). Results: ACC-Cho/NAA values were abnormally high in the short-term abstinent group compared to controls [. F(1,52) = 18.76, p< 0.0001]. No differences were observed between controls and the long-term abstinent group [. F(1,39) = 0.97, p= 0.97]. New evidence of lower ACC-NAA/Cr levels were observed in the short-term abstinent MA abusers compared to controls [. F(1,52) = 23.05, p< 0.0001] and long-term abstinent MA abusers [. F(1,45) = 7.06, p= 0.01]. No differences were observed between long-term abstinent MA abusers and controls [. F(1,39) = 0.48, p= 0.49]. Conclusions: The new findings of relative NAA/Cr normalization across periods of abstinence suggest that adaptive changes following cessation of MA abuse may be broader than initially thought. These changes may contribute to some degree of normalization of neuronal function in the ACC.",
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N2 - Objective: The goal of the present study was to extend our previous findings on long-term methamphetamine (MA) use and drug abstinence on brain metabolite levels in an expanded group of MA-dependent individuals. Methods: Seventeen MA abusers with sustained drug abstinence (1-5 years), 30 MA abusers with short-term drug abstinence (1-6 months) and 24 non-substance using controls were studied using MR spectroscopy (MRS). MRS measures of NAA/Cr, Cho/Cr and Cho/NAA were obtained in the anterior cingulate cortex (ACC) and in the primary visual cortex (PVC). Results: ACC-Cho/NAA values were abnormally high in the short-term abstinent group compared to controls [. F(1,52) = 18.76, p< 0.0001]. No differences were observed between controls and the long-term abstinent group [. F(1,39) = 0.97, p= 0.97]. New evidence of lower ACC-NAA/Cr levels were observed in the short-term abstinent MA abusers compared to controls [. F(1,52) = 23.05, p< 0.0001] and long-term abstinent MA abusers [. F(1,45) = 7.06, p= 0.01]. No differences were observed between long-term abstinent MA abusers and controls [. F(1,39) = 0.48, p= 0.49]. Conclusions: The new findings of relative NAA/Cr normalization across periods of abstinence suggest that adaptive changes following cessation of MA abuse may be broader than initially thought. These changes may contribute to some degree of normalization of neuronal function in the ACC.

AB - Objective: The goal of the present study was to extend our previous findings on long-term methamphetamine (MA) use and drug abstinence on brain metabolite levels in an expanded group of MA-dependent individuals. Methods: Seventeen MA abusers with sustained drug abstinence (1-5 years), 30 MA abusers with short-term drug abstinence (1-6 months) and 24 non-substance using controls were studied using MR spectroscopy (MRS). MRS measures of NAA/Cr, Cho/Cr and Cho/NAA were obtained in the anterior cingulate cortex (ACC) and in the primary visual cortex (PVC). Results: ACC-Cho/NAA values were abnormally high in the short-term abstinent group compared to controls [. F(1,52) = 18.76, p< 0.0001]. No differences were observed between controls and the long-term abstinent group [. F(1,39) = 0.97, p= 0.97]. New evidence of lower ACC-NAA/Cr levels were observed in the short-term abstinent MA abusers compared to controls [. F(1,52) = 23.05, p< 0.0001] and long-term abstinent MA abusers [. F(1,45) = 7.06, p= 0.01]. No differences were observed between long-term abstinent MA abusers and controls [. F(1,39) = 0.48, p= 0.49]. Conclusions: The new findings of relative NAA/Cr normalization across periods of abstinence suggest that adaptive changes following cessation of MA abuse may be broader than initially thought. These changes may contribute to some degree of normalization of neuronal function in the ACC.

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