Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines

E. J. Dunphy, M. A. Beckett, L. H. Thompson, R. R. Weichselbaum

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The human X-ray repair cross-complementing gene 1 (XRCC1) is highly polymorphic in the cells of human head and neck squamous cell carcinoma lines and in a variety of other human cell lines. We describe six patterns seen in Southern analysis of EcoRI-digested genomic DNA. Levels of XRCC1 mRNA vary in cells of human head and neck cell lines as seen in northern blots. Expression of this gene in cell culture does not correlate with radiobiological parameters, clinical outcome, or the DNA restriction fragment length polymorphisms.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalRadiation Research
Volume130
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

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