Expression of Sox genes in tooth development

Katsushige Kawasaki, Maiko Kawasaki, Momoko Watanabe, Erik Idrus, Takahiro Nagai, Shelly Oommen, Takeyasu Maeda, Nobuko Hagiwara, Jianwen Que, Paul T. Sharpe, Atsushi Ohazama

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalInternational Journal of Developmental Biology
Volume59
Issue number10-12
DOIs
StatePublished - 2015

Keywords

  • In situ hybridization
  • Sox
  • Tooth development

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology

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    Kawasaki, K., Kawasaki, M., Watanabe, M., Idrus, E., Nagai, T., Oommen, S., Maeda, T., Hagiwara, N., Que, J., Sharpe, P. T., & Ohazama, A. (2015). Expression of Sox genes in tooth development. International Journal of Developmental Biology, 59(10-12), 471-478. https://doi.org/10.1387/ijdb.150192ao