We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
- Disorders of the nervous system
- Group B streptococcus
- Infectious diseases
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience