Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

Young S. Kim, Jari Honkaniemi, Frank R Sharp, Martin G. Täuber

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalMolecular Brain Research
Volume128
Issue number1
DOIs
StatePublished - Sep 10 2004
Externally publishedYes

Keywords

  • Disorders of the nervous system
  • Ependyma
  • Group B streptococcus
  • IL-1β
  • Infectious diseases
  • Meningitis
  • TNF-α

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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