Abstract
We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-102 |
| Number of pages | 8 |
| Journal | Molecular Brain Research |
| Volume | 128 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 10 2004 |
| Externally published | Yes |
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Keywords
- Disorders of the nervous system
- Ependyma
- Group B streptococcus
- IL-1β
- Infectious diseases
- Meningitis
- TNF-α
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis. / Kim, Young S.; Honkaniemi, Jari; Sharp, Frank R; Täuber, Martin G.
In: Molecular Brain Research, Vol. 128, No. 1, 10.09.2004, p. 95-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis
AU - Kim, Young S.
AU - Honkaniemi, Jari
AU - Sharp, Frank R
AU - Täuber, Martin G.
PY - 2004/9/10
Y1 - 2004/9/10
N2 - We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
AB - We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
KW - Disorders of the nervous system
KW - Ependyma
KW - Group B streptococcus
KW - IL-1β
KW - Infectious diseases
KW - Meningitis
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=4344577909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4344577909&partnerID=8YFLogxK
U2 - 10.1016/j.molbrainres.2004.06.009
DO - 10.1016/j.molbrainres.2004.06.009
M3 - Article
C2 - 15337322
AN - SCOPUS:4344577909
VL - 128
SP - 95
EP - 102
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -