Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

Young S. Kim; Jari Honkaniemi; Frank R Sharp; Martin G. Täuber

doi:10.1016/j.molbrainres.2004.06.009

Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

Young S. Kim, Jari Honkaniemi, Frank R Sharp, Martin G. Täuber

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

Original language	English (US)
Pages (from-to)	95-102
Number of pages	8
Journal	Molecular Brain Research
Volume	128
Issue number	1
DOIs	https://doi.org/10.1016/j.molbrainres.2004.06.009
State	Published - Sep 10 2004
Externally published	Yes

Keywords

Disorders of the nervous system
Ependyma
Group B streptococcus
IL-1β
Infectious diseases
Meningitis
TNF-α

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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title = "Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis",

abstract = "We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.",

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AU - Täuber, Martin G.

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