Abstract
We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
Original language | English (US) |
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Pages (from-to) | 95-102 |
Number of pages | 8 |
Journal | Molecular Brain Research |
Volume | 128 |
Issue number | 1 |
DOIs | |
State | Published - Sep 10 2004 |
Externally published | Yes |
Keywords
- Disorders of the nervous system
- Ependyma
- Group B streptococcus
- IL-1β
- Infectious diseases
- Meningitis
- TNF-α
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience