Abstract
We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-102 |
| Number of pages | 8 |
| Journal | Molecular Brain Research |
| Volume | 128 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 10 2004 |
| Externally published | Yes |
Keywords
- Disorders of the nervous system
- Ependyma
- Group B streptococcus
- IL-1β
- Infectious diseases
- Meningitis
- TNF-α
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
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Cite this
Kim, Y. S., Honkaniemi, J., Sharp, F. R., & Täuber, M. G. (2004). Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis. Molecular Brain Research, 128(1), 95-102. https://doi.org/10.1016/j.molbrainres.2004.06.009