Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

Young S. Kim, Jari Honkaniemi, Frank R Sharp, Martin G. Täuber

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalMolecular Brain Research
Volume128
Issue number1
DOIs
StatePublished - Sep 10 2004
Externally publishedYes

Fingerprint

Interleukin-1
Meningitis
Tumor Necrosis Factor-alpha
Cytokines
Brain
Ependyma
Meninges
Messenger RNA
In Situ Hybridization

Keywords

  • Disorders of the nervous system
  • Ependyma
  • Group B streptococcus
  • IL-1β
  • Infectious diseases
  • Meningitis
  • TNF-α

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis. / Kim, Young S.; Honkaniemi, Jari; Sharp, Frank R; Täuber, Martin G.

In: Molecular Brain Research, Vol. 128, No. 1, 10.09.2004, p. 95-102.

Research output: Contribution to journalArticle

@article{9a174ce1e6b64e9daf174edbd4963c6e,
title = "Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis",
abstract = "We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.",
keywords = "Disorders of the nervous system, Ependyma, Group B streptococcus, IL-1β, Infectious diseases, Meningitis, TNF-α",
author = "Kim, {Young S.} and Jari Honkaniemi and Sharp, {Frank R} and T{\"a}uber, {Martin G.}",
year = "2004",
month = "9",
day = "10",
doi = "10.1016/j.molbrainres.2004.06.009",
language = "English (US)",
volume = "128",
pages = "95--102",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

AU - Kim, Young S.

AU - Honkaniemi, Jari

AU - Sharp, Frank R

AU - Täuber, Martin G.

PY - 2004/9/10

Y1 - 2004/9/10

N2 - We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

AB - We performed mRNA in situ hybridization for TNF-α and IL-1β from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1β mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

KW - Disorders of the nervous system

KW - Ependyma

KW - Group B streptococcus

KW - IL-1β

KW - Infectious diseases

KW - Meningitis

KW - TNF-α

UR - http://www.scopus.com/inward/record.url?scp=4344577909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344577909&partnerID=8YFLogxK

U2 - 10.1016/j.molbrainres.2004.06.009

DO - 10.1016/j.molbrainres.2004.06.009

M3 - Article

C2 - 15337322

AN - SCOPUS:4344577909

VL - 128

SP - 95

EP - 102

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -