Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning

Jianwei Jiao, Akira Nakajima, William G.M. Janssen, Vytautas P. Bindokas, Xiaoli Xiong, John Morrison, James R. Brorson, Ya Ping Tang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice, These results indicate that changes in the expression of gene(s) that are involved in regulatinq synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning.

Original languageEnglish (US)
Article numbere1684
JournalPLoS One
Volume3
Issue number2
DOIs
StatePublished - Feb 27 2008
Externally publishedYes

Fingerprint

granules
learning
Learning
Gene-Environment Interaction
Motor Skills
cells
genotype-environment interaction
Neuronal Plasticity
Genes
N-Methyl-D-Aspartate Receptors
Cerebellum
Transgenic Mice
motor development
Gene Expression
mice
cerebellum
Plasticity
developmental stages
genetically modified organisms
gene expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. / Jiao, Jianwei; Nakajima, Akira; Janssen, William G.M.; Bindokas, Vytautas P.; Xiong, Xiaoli; Morrison, John; Brorson, James R.; Tang, Ya Ping.

In: PLoS One, Vol. 3, No. 2, e1684, 27.02.2008.

Research output: Contribution to journalArticle

Jiao, Jianwei ; Nakajima, Akira ; Janssen, William G.M. ; Bindokas, Vytautas P. ; Xiong, Xiaoli ; Morrison, John ; Brorson, James R. ; Tang, Ya Ping. / Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. In: PLoS One. 2008 ; Vol. 3, No. 2.
@article{fdb89d3335b34162916e022c9161eb46,
title = "Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning",
abstract = "It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice, These results indicate that changes in the expression of gene(s) that are involved in regulatinq synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning.",
author = "Jianwei Jiao and Akira Nakajima and Janssen, {William G.M.} and Bindokas, {Vytautas P.} and Xiaoli Xiong and John Morrison and Brorson, {James R.} and Tang, {Ya Ping}",
year = "2008",
month = "2",
day = "27",
doi = "10.1371/journal.pone.0001684",
language = "English (US)",
volume = "3",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning

AU - Jiao, Jianwei

AU - Nakajima, Akira

AU - Janssen, William G.M.

AU - Bindokas, Vytautas P.

AU - Xiong, Xiaoli

AU - Morrison, John

AU - Brorson, James R.

AU - Tang, Ya Ping

PY - 2008/2/27

Y1 - 2008/2/27

N2 - It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice, These results indicate that changes in the expression of gene(s) that are involved in regulatinq synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning.

AB - It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice, These results indicate that changes in the expression of gene(s) that are involved in regulatinq synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning.

UR - http://www.scopus.com/inward/record.url?scp=45949097715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45949097715&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0001684

DO - 10.1371/journal.pone.0001684

M3 - Article

C2 - 18301761

AN - SCOPUS:45949097715

VL - 3

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e1684

ER -