Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning

Jianwei Jiao, Akira Nakajima, William G.M. Janssen, Vytautas P. Bindokas, Xiaoli Xiong, John Morrison, James R. Brorson, Ya Ping Tang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice, These results indicate that changes in the expression of gene(s) that are involved in regulatinq synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning.

Original languageEnglish (US)
Article numbere1684
JournalPLoS One
Volume3
Issue number2
DOIs
StatePublished - Feb 27 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Jiao, J., Nakajima, A., Janssen, W. G. M., Bindokas, V. P., Xiong, X., Morrison, J., Brorson, J. R., & Tang, Y. P. (2008). Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. PLoS One, 3(2), [e1684]. https://doi.org/10.1371/journal.pone.0001684