Abstract
Expression of low-affinity neurotrophin receptor (p75(NTR)) was immunohistochemically examined in the peripheral nerve trunks, dorsal root ganglia, sympathetic nerve ganglia and spinal cords in various human neurological diseases manifesting peripheral neuropathies. p75(NTR) was expressed in the nerves with axonal degeneration, and was also prominent in the nerves with newly regenerating axons. In contrast, axonal pathology tended to reduce the expression of p75(NTR) in the neuronal perikarya of the dorsal root genglion and sympathetic nerve ganglion neurons. In the ventral and lateral horn cells, the p75(NTR) immunoreactivity was not detected in the normal and diseased nerves except for amyloid polyneuropathy. These p75(NTR) expressions in the diseased human peripheral nervous tissues would be regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 597-604 |
| Number of pages | 8 |
| Journal | Acta Neuropathologica |
| Volume | 95 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Dorsal root ganglia
- Nerve regeneration
- p75(NTR)
- Spinal cord
- Sympathetic ganglia
ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine
- Neuroscience(all)
Cite this
Expression of low-affinity neurotrophin receptor p75(NTR) in the peripheral nervous system of human neuropathies. / Yamamoto, M.; Li, M.; Nagamatsu, M.; Ito, Takayuki; Mutoh, T.; Mitsuma, T.; Sobue, G.
In: Acta Neuropathologica, Vol. 95, No. 6, 1998, p. 597-604.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of low-affinity neurotrophin receptor p75(NTR) in the peripheral nervous system of human neuropathies
AU - Yamamoto, M.
AU - Li, M.
AU - Nagamatsu, M.
AU - Ito, Takayuki
AU - Mutoh, T.
AU - Mitsuma, T.
AU - Sobue, G.
PY - 1998
Y1 - 1998
N2 - Expression of low-affinity neurotrophin receptor (p75(NTR)) was immunohistochemically examined in the peripheral nerve trunks, dorsal root ganglia, sympathetic nerve ganglia and spinal cords in various human neurological diseases manifesting peripheral neuropathies. p75(NTR) was expressed in the nerves with axonal degeneration, and was also prominent in the nerves with newly regenerating axons. In contrast, axonal pathology tended to reduce the expression of p75(NTR) in the neuronal perikarya of the dorsal root genglion and sympathetic nerve ganglion neurons. In the ventral and lateral horn cells, the p75(NTR) immunoreactivity was not detected in the normal and diseased nerves except for amyloid polyneuropathy. These p75(NTR) expressions in the diseased human peripheral nervous tissues would be regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair.
AB - Expression of low-affinity neurotrophin receptor (p75(NTR)) was immunohistochemically examined in the peripheral nerve trunks, dorsal root ganglia, sympathetic nerve ganglia and spinal cords in various human neurological diseases manifesting peripheral neuropathies. p75(NTR) was expressed in the nerves with axonal degeneration, and was also prominent in the nerves with newly regenerating axons. In contrast, axonal pathology tended to reduce the expression of p75(NTR) in the neuronal perikarya of the dorsal root genglion and sympathetic nerve ganglion neurons. In the ventral and lateral horn cells, the p75(NTR) immunoreactivity was not detected in the normal and diseased nerves except for amyloid polyneuropathy. These p75(NTR) expressions in the diseased human peripheral nervous tissues would be regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair.
KW - Dorsal root ganglia
KW - Nerve regeneration
KW - p75(NTR)
KW - Spinal cord
KW - Sympathetic ganglia
UR - http://www.scopus.com/inward/record.url?scp=0031781456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031781456&partnerID=8YFLogxK
U2 - 10.1007/s004010050846
DO - 10.1007/s004010050846
M3 - Article
VL - 95
SP - 597
EP - 604
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 0001-6322
IS - 6
ER -