Expression of human milk proteins in plants

Bo Lönnerdal

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Human milk proteins are believed to have a multitude of biological activities benefiting the newborn infant. Such functions include antibacterial and antiviral activities, enhancement of the immune system and increased nutrient absorption. To date, only breast-fed infants have been exposed to these proteins. However, by using genetic engineering it is now possible to express these proteins in plants, such as rice, at very high levels. Recombinant human milk proteins can subsequently be added to infant formula and baby foods. Prior to such addition, safety tests and efficacy trials need to be conducted. The safety tests will initially be done in rats and then in humans. The efficacy trials should also evaluate stability against heat treatment (processing), pH (stomach conditions) and proteolytic enzymes (digestion). To date, we have expressed recombinant human lactoferrin, lysozyme and α1-antitrypsin in rice at very high expression levels. These recombinant proteins showed a stability and activities similar to those of the native milk proteins, suggesting that they may be able to exert biological activities in infants when added to formula or baby foods.

Original languageEnglish (US)
JournalJournal of the American College of Nutrition
Volume21
Issue number3 SUPPL.
StatePublished - 2002

Fingerprint

human milk proteins
infant foods
Milk Proteins
Human Milk
bioactive properties
Infant Formula
rice
Food
lactoferrin
milk proteins
infant formulas
plant proteins
lysozyme
genetic engineering
recombinant proteins
breasts
immune system
Safety
Plant Proteins
neonates

Keywords

  • Human milk proteins
  • Plant expression
  • Recombinant milk proteins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Expression of human milk proteins in plants. / Lönnerdal, Bo.

In: Journal of the American College of Nutrition, Vol. 21, No. 3 SUPPL., 2002.

Research output: Contribution to journalArticle

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