Expression of CD44s and CD44v6 in lung cancer and their correlation with prognostic factors

Alaa M Afify, Stacey Tate, Blythe Durbin-Johnson, David M Rocke, Thomas Konia

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: cd44, a transmembrane glycoprotein receptor, plays a major role in tumor progression and metastasis. objective: to evaluate the expression of cd44 standard (cd44s) and its variant 6 (cd44v6) in normal and neoplastic lung tissue and correlate it with prognostic factors in lung cancer. Methods: the study included 52 non-small cell lung carcinomas (nScLc) (21 squamous cell carcinomas and 31 adenocarci-nomas), 15 small cell lung carcinomas (ScLc) and 8 carcinoid tumors. Expression of cd44s and cd44v6 was evaluated by immunohistochemistry and correlated with lung cancer prognostic factors. Results: All squamous cell carcinomas expressed both cd44s and cd44v6. Adenocarcinomas expressed cd44s in 39% of cases and cd44v6 in 45%. carcinoid tumors expressed only cd44s in 88% of cases. All ScLcs were negative for both cd44s and cd44v6. A restricted panel consisting of cd44s and cd44v6 will discriminate nScLc from ScLc with a sensitivity of 67% and a specifcity of 100%. In adenocarcinoma cd44s expression was signifcantly correlated with lymph node metastases (p=0.007) while cd44v6 expression was more signifcantly associated with tumor size (p=0.0032). Conclusions: cd44s and cd44v6 are expressed in certain types of lung cancer. In adenocarcinoma cd44s and cd44v6 expression is signifcantly correlated with lymph node metastases and tumor size.

Original languageEnglish (US)
Pages (from-to)50-57
Number of pages8
JournalInternational Journal of Biological Markers
Volume26
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • CD44s
  • CD44v6
  • Lung cancer
  • Prognostic marker

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

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