Expression of c-fos protein in brain: Metabolic mapping at the cellular level

S. M. Sagar, Frank R Sharp, T. Curran

Research output: Contribution to journalArticlepeer-review

1742 Scopus citations


The proto-oncogene c-fos is expressed in neurons in response to direct stimulation by growth factors and neurotransmitters. In order to determine whether die c-fos protein (Fos) and Fos-related proteins can be induced in response to polysynaptic activation, rat hindlimb motor/sensory cortex was stimulated electrically and Fos expression examined immunohistochemically. Three hours after the onset of stimulation, focal nuclear Fos staining was seen in motor and sensory thalamus, pontine nuclei, globus pallidus, and cerebellum. Moreover, 24-hour water deprivation resulted in Fos expression in paraventricular and supraoptic nuclei. Fos immunohistochemistry therefore provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways.

Original languageEnglish (US)
Pages (from-to)1328-1331
Number of pages4
JournalScience Science
Issue number4857
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • General


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