Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques

Morteza Roodgar, Andrew Lackner, Deepak Kaushal, Sumathi Sankaran-Walters, Satya Dandekar, Jessica Satkoski Trask, Christiana Drake, David Glenn Smith

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The expression of ten tuberculosis candidate genes in lung and lymph nodes of cynomologus macaques vaccinated and experimentally infected with Mycobacterium tuberculosis (Mtb) was quantified. The expression of TNFα, IL10, IL1β, TLR4, IL17, IL6, IL12, and iNOS in the lungs of vaccinated animals was higher than that of non-vaccinated animals.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalJournal of Medical Primatology
Volume42
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Cynomolgus macaques
  • Gene expression
  • IL12
  • IL17
  • INOS
  • Tuberculosis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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