Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques

Morteza Roodgar; Andrew Lackner; Deepak Kaushal; Sumathi Sankaran-Walters; Satya Dandekar; Jessica Satkoski Trask; Christiana Drake; David Glenn Smith

doi:10.1111/jmp.12040

Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques

Morteza Roodgar, Andrew Lackner, Deepak Kaushal, Sumathi Sankaran-Walters, Satya Dandekar, Jessica Satkoski Trask, Christiana Drake, David Glenn Smith

Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The expression of ten tuberculosis candidate genes in lung and lymph nodes of cynomologus macaques vaccinated and experimentally infected with Mycobacterium tuberculosis (Mtb) was quantified. The expression of TNFα, IL10, IL1β, TLR4, IL17, IL6, IL12, and iNOS in the lungs of vaccinated animals was higher than that of non-vaccinated animals.

Original language	English (US)
Pages (from-to)	161-164
Number of pages	4
Journal	Journal of Medical Primatology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1111/jmp.12040
State	Published - Jun 2013

Keywords

Cynomolgus macaques
Gene expression
IL12
IL17
INOS
Tuberculosis

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/jmp.12040

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Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques. / Roodgar, Morteza; Lackner, Andrew; Kaushal, Deepak; Sankaran-Walters, Sumathi ; Dandekar, Satya; Satkoski Trask, Jessica; Drake, Christiana; Smith, David Glenn.

In: Journal of Medical Primatology, Vol. 42, No. 3, 06.2013, p. 161-164.

Research output: Contribution to journal › Article › peer-review

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abstract = "The expression of ten tuberculosis candidate genes in lung and lymph nodes of cynomologus macaques vaccinated and experimentally infected with Mycobacterium tuberculosis (Mtb) was quantified. The expression of TNFα, IL10, IL1β, TLR4, IL17, IL6, IL12, and iNOS in the lungs of vaccinated animals was higher than that of non-vaccinated animals.",

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AU - Dandekar, Satya

AU - Satkoski Trask, Jessica

AU - Drake, Christiana

AU - Smith, David Glenn

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AB - The expression of ten tuberculosis candidate genes in lung and lymph nodes of cynomologus macaques vaccinated and experimentally infected with Mycobacterium tuberculosis (Mtb) was quantified. The expression of TNFα, IL10, IL1β, TLR4, IL17, IL6, IL12, and iNOS in the lungs of vaccinated animals was higher than that of non-vaccinated animals.

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KW - IL17

KW - INOS

KW - Tuberculosis

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Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques

Abstract

Keywords

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