Expression domains of murine ephrin-A5 in the pituitary and hypothalamus

Konstantinos Zarbalis, Wolfgang Wurst

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Using in situ hybridization on whole-mounts and sections of mouse embryos we have visualized the pattern of expression for the Eph receptor ligand ephrin-A5. Non neuronal expression domains include the ectoderm of the branchial arches, the ectoderm and mesenchyme surrounding the dorsal root ganglia, the intervertebral discs, maxillary and mandibulary mesenchymal elements as well as the nasal mesenchyme and ectoderm. Within the developing nervous system, ephrin-A5 expression is very dynamic. Besides the midbrain it is also expressed in the hypothalamus, and the neurohypohysis that we studied here in more detail. Hypothalamus expression of ephrin-A5 demarks distinct nuclei, persists throughout embryonic development, and can be seen also in the adult. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalMechanisms of Development
Issue number1-2
StatePublished - May 1 2000
Externally publishedYes


  • Axon guidance
  • Brain development
  • Eph
  • ephrin-A5
  • Hypothalamus
  • Mouse embryo
  • Pituitary

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience


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