Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma

Daniel P. Widney, Dorina Gui, Laura M. Popoviciu, Jonathan W. Said, Elizabeth C. Breen, Xin Huang, Christina M.R. Kitchen, Juan M. Alcantar, Jeffrey B. Smith, Roger Detels, Otoniel Martínez-Maza

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Abstract

Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.

Original languageEnglish (US)
Article number164586
JournalAIDS Research and Treatment
Volume2010
DOIs
StatePublished - Dec 1 2010

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CXCR5 Receptors
Chemokine CXCL13
AIDS-Related Lymphoma
Non-Hodgkin's Lymphoma
B-Lymphocytes
Cell Line
Chemotaxis
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma. / Widney, Daniel P.; Gui, Dorina; Popoviciu, Laura M.; Said, Jonathan W.; Breen, Elizabeth C.; Huang, Xin; Kitchen, Christina M.R.; Alcantar, Juan M.; Smith, Jeffrey B.; Detels, Roger; Martínez-Maza, Otoniel.

In: AIDS Research and Treatment, Vol. 2010, 164586, 01.12.2010.

Research output: Contribution to journalArticle

Widney, DP, Gui, D, Popoviciu, LM, Said, JW, Breen, EC, Huang, X, Kitchen, CMR, Alcantar, JM, Smith, JB, Detels, R & Martínez-Maza, O 2010, 'Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma', AIDS Research and Treatment, vol. 2010, 164586. https://doi.org/10.1155/2010/164586
Widney, Daniel P. ; Gui, Dorina ; Popoviciu, Laura M. ; Said, Jonathan W. ; Breen, Elizabeth C. ; Huang, Xin ; Kitchen, Christina M.R. ; Alcantar, Juan M. ; Smith, Jeffrey B. ; Detels, Roger ; Martínez-Maza, Otoniel. / Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma. In: AIDS Research and Treatment. 2010 ; Vol. 2010.
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AU - Said, Jonathan W.

AU - Breen, Elizabeth C.

AU - Huang, Xin

AU - Kitchen, Christina M.R.

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AU - Smith, Jeffrey B.

AU - Detels, Roger

AU - Martínez-Maza, Otoniel

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N2 - Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.

AB - Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.

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