Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma

Daniel P. Widney, Dorina Gui, Laura M. Popoviciu, Jonathan W. Said, Elizabeth C. Breen, Xin Huang, Christina M.R. Kitchen, Juan M. Alcantar, Jeffrey B. Smith, Roger Detels, Otoniel Martínez-Maza

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23 Scopus citations

Abstract

Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.

Original languageEnglish (US)
Article number164586
JournalAIDS Research and Treatment
Volume2010
DOIs
StatePublished - Dec 1 2010

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Widney, D. P., Gui, D., Popoviciu, L. M., Said, J. W., Breen, E. C., Huang, X., Kitchen, C. M. R., Alcantar, J. M., Smith, J. B., Detels, R., & Martínez-Maza, O. (2010). Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma. AIDS Research and Treatment, 2010, [164586]. https://doi.org/10.1155/2010/164586