Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma

Daniel P. Widney, Dorina Gui, Laura M. Popoviciu, Jonathan W. Said, Elizabeth C. Breen, Xin Huang, Christina M.R. Kitchen, Juan M. Alcantar, Jeffrey B. Smith, Roger Detels, Otoniel Martínez-Maza

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24 Scopus citations

Abstract

Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.

Original languageEnglish (US)
Article number164586
JournalAIDS Research and Treatment
Volume2010
DOIs
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Widney, D. P., Gui, D., Popoviciu, L. M., Said, J. W., Breen, E. C., Huang, X., Kitchen, C. M. R., Alcantar, J. M., Smith, J. B., Detels, R., & Martínez-Maza, O. (2010). Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-associated non-Hodgkin's lymphoma. AIDS Research and Treatment, 2010, [164586]. https://doi.org/10.1155/2010/164586