Abstract
BACKGROUND: Hydroxylated polychlorinated biphenyls (OH-PCBs), unlike PCBs, are in general readily excreted yet are still detected in humans and animals. Active transport of OH-PCBs across the placenta and hydroxylation of PCBs by the fetus suggest the potential for greater impact on the fetus compared with the parent PCB compounds, but little is known about their health effects, particularly in humans. OBJECTIVES: The objective of this study was to evaluate the associations between prenatal OH-PCB exposure and neurodevelopment in children at 16 months of age in eastern Slovakia. METHODS: A birth cohort (n = 1,134) was enrolled during 2002-2004. We analyzed six OH-PCB metabolites (4-OH-CB-107, 3-OH-CB-153, 4-OH-CB-146, 3′-OH-CB-138, 4-OH-CB-187, and 4′-OH-CB-172) in a subset of the cohort. The Bayley Scales of Infant Development were administered to the children at the 16-month follow-up visit. We developed multiple linear regression models predicting standardized scores for the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from maternal (n = 147) and cord (n = 80) serum OH-PCB concentrations, adjusting for sex of child, district, HOME (Home Observation for Measurement of the Environment) score, and maternal score on Raven's Progressive Matrices. RESULTS: Cord 4-OH-CB-107 was significantly associated with lower MDI (β = -2.27; p = 0.01) and PDI (β = -4.50; p = 0.004). Also, maternal 4-OH-CB-107 was significantly associated with lower MDI (β = -1.76; p = 0.03) but not PDI. No other OH-PCB metabolites were associated with decreased PDI or MDI. CONCLUSIONS: Our findings showed a significant association of 4-OH-CB-107 with decreased MDI, which can possibly be mediated by endocrine disruption, altered neurotransmitter functions, or reduced thyroid hormone concentrations in brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1600-1606 |
| Number of pages | 7 |
| Journal | Environmental Health Perspectives |
| Volume | 117 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2009 |
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Keywords
- Bayley scales of infant development
- Hydroxylated PCBs
- Slovakia
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Public Health, Environmental and Occupational Health
Cite this
Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia. / Park, Hye Youn; Park, June Soo; Sovcikova, Eva; Kocan, Anton; Linderholm, Linda; Bergman, Ake; Trnovec, Tomas; Hertz-Picciotto, Irva.
In: Environmental Health Perspectives, Vol. 117, No. 10, 10.2009, p. 1600-1606.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia
AU - Park, Hye Youn
AU - Park, June Soo
AU - Sovcikova, Eva
AU - Kocan, Anton
AU - Linderholm, Linda
AU - Bergman, Ake
AU - Trnovec, Tomas
AU - Hertz-Picciotto, Irva
PY - 2009/10
Y1 - 2009/10
N2 - BACKGROUND: Hydroxylated polychlorinated biphenyls (OH-PCBs), unlike PCBs, are in general readily excreted yet are still detected in humans and animals. Active transport of OH-PCBs across the placenta and hydroxylation of PCBs by the fetus suggest the potential for greater impact on the fetus compared with the parent PCB compounds, but little is known about their health effects, particularly in humans. OBJECTIVES: The objective of this study was to evaluate the associations between prenatal OH-PCB exposure and neurodevelopment in children at 16 months of age in eastern Slovakia. METHODS: A birth cohort (n = 1,134) was enrolled during 2002-2004. We analyzed six OH-PCB metabolites (4-OH-CB-107, 3-OH-CB-153, 4-OH-CB-146, 3′-OH-CB-138, 4-OH-CB-187, and 4′-OH-CB-172) in a subset of the cohort. The Bayley Scales of Infant Development were administered to the children at the 16-month follow-up visit. We developed multiple linear regression models predicting standardized scores for the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from maternal (n = 147) and cord (n = 80) serum OH-PCB concentrations, adjusting for sex of child, district, HOME (Home Observation for Measurement of the Environment) score, and maternal score on Raven's Progressive Matrices. RESULTS: Cord 4-OH-CB-107 was significantly associated with lower MDI (β = -2.27; p = 0.01) and PDI (β = -4.50; p = 0.004). Also, maternal 4-OH-CB-107 was significantly associated with lower MDI (β = -1.76; p = 0.03) but not PDI. No other OH-PCB metabolites were associated with decreased PDI or MDI. CONCLUSIONS: Our findings showed a significant association of 4-OH-CB-107 with decreased MDI, which can possibly be mediated by endocrine disruption, altered neurotransmitter functions, or reduced thyroid hormone concentrations in brain.
AB - BACKGROUND: Hydroxylated polychlorinated biphenyls (OH-PCBs), unlike PCBs, are in general readily excreted yet are still detected in humans and animals. Active transport of OH-PCBs across the placenta and hydroxylation of PCBs by the fetus suggest the potential for greater impact on the fetus compared with the parent PCB compounds, but little is known about their health effects, particularly in humans. OBJECTIVES: The objective of this study was to evaluate the associations between prenatal OH-PCB exposure and neurodevelopment in children at 16 months of age in eastern Slovakia. METHODS: A birth cohort (n = 1,134) was enrolled during 2002-2004. We analyzed six OH-PCB metabolites (4-OH-CB-107, 3-OH-CB-153, 4-OH-CB-146, 3′-OH-CB-138, 4-OH-CB-187, and 4′-OH-CB-172) in a subset of the cohort. The Bayley Scales of Infant Development were administered to the children at the 16-month follow-up visit. We developed multiple linear regression models predicting standardized scores for the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from maternal (n = 147) and cord (n = 80) serum OH-PCB concentrations, adjusting for sex of child, district, HOME (Home Observation for Measurement of the Environment) score, and maternal score on Raven's Progressive Matrices. RESULTS: Cord 4-OH-CB-107 was significantly associated with lower MDI (β = -2.27; p = 0.01) and PDI (β = -4.50; p = 0.004). Also, maternal 4-OH-CB-107 was significantly associated with lower MDI (β = -1.76; p = 0.03) but not PDI. No other OH-PCB metabolites were associated with decreased PDI or MDI. CONCLUSIONS: Our findings showed a significant association of 4-OH-CB-107 with decreased MDI, which can possibly be mediated by endocrine disruption, altered neurotransmitter functions, or reduced thyroid hormone concentrations in brain.
KW - Bayley scales of infant development
KW - Hydroxylated PCBs
KW - Slovakia
UR - http://www.scopus.com/inward/record.url?scp=67349134846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349134846&partnerID=8YFLogxK
U2 - 10.1289/ehp.0900611
DO - 10.1289/ehp.0900611
M3 - Article
C2 - 20019912
AN - SCOPUS:67349134846
VL - 117
SP - 1600
EP - 1606
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 10
ER -