Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia

Hye Youn Park, June Soo Park, Eva Sovcikova, Anton Kocan, Linda Linderholm, Ake Bergman, Tomas Trnovec, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Hydroxylated polychlorinated biphenyls (OH-PCBs), unlike PCBs, are in general readily excreted yet are still detected in humans and animals. Active transport of OH-PCBs across the placenta and hydroxylation of PCBs by the fetus suggest the potential for greater impact on the fetus compared with the parent PCB compounds, but little is known about their health effects, particularly in humans. OBJECTIVES: The objective of this study was to evaluate the associations between prenatal OH-PCB exposure and neurodevelopment in children at 16 months of age in eastern Slovakia. METHODS: A birth cohort (n = 1,134) was enrolled during 2002-2004. We analyzed six OH-PCB metabolites (4-OH-CB-107, 3-OH-CB-153, 4-OH-CB-146, 3′-OH-CB-138, 4-OH-CB-187, and 4′-OH-CB-172) in a subset of the cohort. The Bayley Scales of Infant Development were administered to the children at the 16-month follow-up visit. We developed multiple linear regression models predicting standardized scores for the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from maternal (n = 147) and cord (n = 80) serum OH-PCB concentrations, adjusting for sex of child, district, HOME (Home Observation for Measurement of the Environment) score, and maternal score on Raven's Progressive Matrices. RESULTS: Cord 4-OH-CB-107 was significantly associated with lower MDI (β = -2.27; p = 0.01) and PDI (β = -4.50; p = 0.004). Also, maternal 4-OH-CB-107 was significantly associated with lower MDI (β = -1.76; p = 0.03) but not PDI. No other OH-PCB metabolites were associated with decreased PDI or MDI. CONCLUSIONS: Our findings showed a significant association of 4-OH-CB-107 with decreased MDI, which can possibly be mediated by endocrine disruption, altered neurotransmitter functions, or reduced thyroid hormone concentrations in brain.

Original languageEnglish (US)
Pages (from-to)1600-1606
Number of pages7
JournalEnvironmental Health Perspectives
Volume117
Issue number10
DOIs
StatePublished - Oct 2009

Fingerprint

Slovakia
Polychlorinated Biphenyls
2,4,5,2',4',5'-hexachlorobiphenyl
Mothers
hydroxide ion
Linear Models
Fetus
Crows
Active Biological Transport
Hydroxylation
Child Development
Thyroid Hormones

Keywords

  • Bayley scales of infant development
  • Hydroxylated PCBs
  • Slovakia

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia. / Park, Hye Youn; Park, June Soo; Sovcikova, Eva; Kocan, Anton; Linderholm, Linda; Bergman, Ake; Trnovec, Tomas; Hertz-Picciotto, Irva.

In: Environmental Health Perspectives, Vol. 117, No. 10, 10.2009, p. 1600-1606.

Research output: Contribution to journalArticle

Park, Hye Youn ; Park, June Soo ; Sovcikova, Eva ; Kocan, Anton ; Linderholm, Linda ; Bergman, Ake ; Trnovec, Tomas ; Hertz-Picciotto, Irva. / Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in eastern Slovakia. In: Environmental Health Perspectives. 2009 ; Vol. 117, No. 10. pp. 1600-1606.
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AU - Park, Hye Youn

AU - Park, June Soo

AU - Sovcikova, Eva

AU - Kocan, Anton

AU - Linderholm, Linda

AU - Bergman, Ake

AU - Trnovec, Tomas

AU - Hertz-Picciotto, Irva

PY - 2009/10

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N2 - BACKGROUND: Hydroxylated polychlorinated biphenyls (OH-PCBs), unlike PCBs, are in general readily excreted yet are still detected in humans and animals. Active transport of OH-PCBs across the placenta and hydroxylation of PCBs by the fetus suggest the potential for greater impact on the fetus compared with the parent PCB compounds, but little is known about their health effects, particularly in humans. OBJECTIVES: The objective of this study was to evaluate the associations between prenatal OH-PCB exposure and neurodevelopment in children at 16 months of age in eastern Slovakia. METHODS: A birth cohort (n = 1,134) was enrolled during 2002-2004. We analyzed six OH-PCB metabolites (4-OH-CB-107, 3-OH-CB-153, 4-OH-CB-146, 3′-OH-CB-138, 4-OH-CB-187, and 4′-OH-CB-172) in a subset of the cohort. The Bayley Scales of Infant Development were administered to the children at the 16-month follow-up visit. We developed multiple linear regression models predicting standardized scores for the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from maternal (n = 147) and cord (n = 80) serum OH-PCB concentrations, adjusting for sex of child, district, HOME (Home Observation for Measurement of the Environment) score, and maternal score on Raven's Progressive Matrices. RESULTS: Cord 4-OH-CB-107 was significantly associated with lower MDI (β = -2.27; p = 0.01) and PDI (β = -4.50; p = 0.004). Also, maternal 4-OH-CB-107 was significantly associated with lower MDI (β = -1.76; p = 0.03) but not PDI. No other OH-PCB metabolites were associated with decreased PDI or MDI. CONCLUSIONS: Our findings showed a significant association of 4-OH-CB-107 with decreased MDI, which can possibly be mediated by endocrine disruption, altered neurotransmitter functions, or reduced thyroid hormone concentrations in brain.

AB - BACKGROUND: Hydroxylated polychlorinated biphenyls (OH-PCBs), unlike PCBs, are in general readily excreted yet are still detected in humans and animals. Active transport of OH-PCBs across the placenta and hydroxylation of PCBs by the fetus suggest the potential for greater impact on the fetus compared with the parent PCB compounds, but little is known about their health effects, particularly in humans. OBJECTIVES: The objective of this study was to evaluate the associations between prenatal OH-PCB exposure and neurodevelopment in children at 16 months of age in eastern Slovakia. METHODS: A birth cohort (n = 1,134) was enrolled during 2002-2004. We analyzed six OH-PCB metabolites (4-OH-CB-107, 3-OH-CB-153, 4-OH-CB-146, 3′-OH-CB-138, 4-OH-CB-187, and 4′-OH-CB-172) in a subset of the cohort. The Bayley Scales of Infant Development were administered to the children at the 16-month follow-up visit. We developed multiple linear regression models predicting standardized scores for the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from maternal (n = 147) and cord (n = 80) serum OH-PCB concentrations, adjusting for sex of child, district, HOME (Home Observation for Measurement of the Environment) score, and maternal score on Raven's Progressive Matrices. RESULTS: Cord 4-OH-CB-107 was significantly associated with lower MDI (β = -2.27; p = 0.01) and PDI (β = -4.50; p = 0.004). Also, maternal 4-OH-CB-107 was significantly associated with lower MDI (β = -1.76; p = 0.03) but not PDI. No other OH-PCB metabolites were associated with decreased PDI or MDI. CONCLUSIONS: Our findings showed a significant association of 4-OH-CB-107 with decreased MDI, which can possibly be mediated by endocrine disruption, altered neurotransmitter functions, or reduced thyroid hormone concentrations in brain.

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