Exposure to environmental tobacco smoke during pregnancy in rats yields less effect on indices of brain cell number and size than does postnatal exposure

Sidney M. Gospe, John A. Joyce, Joseph R. Siebert, Rhona M. Jack, Kent E Pinkerton

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

While there is evidence that human perinatal exposure to environmental tobacco smoke (ETS) can result in an increased risk of respiratory disorders and sudden infant death syndrome, evidence linking ETS exposure to neurodevelopmental handicaps is suggestive but less compelling. We previously noted that postnatal ETS exposure, rather than prenatal exposure, resulted in reduced concentration of hindbrain DNA and increased protein/DNA ratio when rat brain tissue was studied at 9 weeks postnatal age. We have now evaluated the effects of ETS exposure during pregnancy on brain development by assaying brain tissue at term. ETS exposure had no detectable effects on regional brain concentrations of DNA, protein and cholesterol or on protein/DNA and cholesterol/DNA ratios. While ETS exposure during pregnancy also had no detectable effects on the weights of the individual fetuses or on the weights of various organs, certain regions of the fetal skeleton demonstrated accelerated ossification. The findings of this study are contrasted to the developmental effects of both nicotine and ETS in Rhesus macaques. Additional studies designed specifically to assess the risk of prenatal ETS exposure on brain development in non-human primates and other precocial species are warranted.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalReproductive Toxicology
Volume27
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Tobacco
Environmental Exposure
Cell Size
Smoke
Rats
Brain
Cell Count
Pregnancy
DNA
Cholesterol
Tissue
Rhombencephalon
Proteins
Sudden Infant Death
Organ Size
Macaca mulatta
Nicotine
Osteogenesis
Skeleton
Primates

Keywords

  • Brain development
  • Environmental tobacco smoke
  • Fetus
  • Rat
  • Sidestream smoke

ASJC Scopus subject areas

  • Toxicology

Cite this

Exposure to environmental tobacco smoke during pregnancy in rats yields less effect on indices of brain cell number and size than does postnatal exposure. / Gospe, Sidney M.; Joyce, John A.; Siebert, Joseph R.; Jack, Rhona M.; Pinkerton, Kent E.

In: Reproductive Toxicology, Vol. 27, No. 1, 01.2009, p. 22-27.

Research output: Contribution to journalArticle

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