TY - JOUR
T1 - Exposing Toxoplasma gondii hiding inside the vacuole
T2 - a role for GBPs, autophagy and host cell death
AU - Saeij, Jeroen
AU - Frickel, Eva Maria
PY - 2017/12/1
Y1 - 2017/12/1
N2 - The intracellular parasite Toxoplasma gondii resides inside a vacuole, which shields it from the host's intracellular defense mechanisms. The cytokine interferon gamma (IFNγ) upregulates host cell effector pathways that are able to destroy the vacuole, restrict parasite growth and induce host cell death. Interferon-inducible GTPases such as the Guanylate Binding Proteins (GBPs), autophagy proteins and ubiquitin-driven mechanisms play important roles in Toxoplasma control in mice and partly also in humans. The host inflammasome is regulated by GBPs in response to bacterial infection in murine cells and may also respond to Toxoplasma infection. Elucidation of murine Toxoplasma defense mechanisms are guiding studies on human cells, while inevitably leading to the discovery of human-specific pathways that often function in a cell type-dependent manner.
AB - The intracellular parasite Toxoplasma gondii resides inside a vacuole, which shields it from the host's intracellular defense mechanisms. The cytokine interferon gamma (IFNγ) upregulates host cell effector pathways that are able to destroy the vacuole, restrict parasite growth and induce host cell death. Interferon-inducible GTPases such as the Guanylate Binding Proteins (GBPs), autophagy proteins and ubiquitin-driven mechanisms play important roles in Toxoplasma control in mice and partly also in humans. The host inflammasome is regulated by GBPs in response to bacterial infection in murine cells and may also respond to Toxoplasma infection. Elucidation of murine Toxoplasma defense mechanisms are guiding studies on human cells, while inevitably leading to the discovery of human-specific pathways that often function in a cell type-dependent manner.
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U2 - 10.1016/j.mib.2017.10.021
DO - 10.1016/j.mib.2017.10.021
M3 - Review article
C2 - 29141239
AN - SCOPUS:85034051131
VL - 40
SP - 72
EP - 80
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
ER -