Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death

Jeroen Saeij, Eva Maria Frickel

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

The intracellular parasite Toxoplasma gondii resides inside a vacuole, which shields it from the host's intracellular defense mechanisms. The cytokine interferon gamma (IFNγ) upregulates host cell effector pathways that are able to destroy the vacuole, restrict parasite growth and induce host cell death. Interferon-inducible GTPases such as the Guanylate Binding Proteins (GBPs), autophagy proteins and ubiquitin-driven mechanisms play important roles in Toxoplasma control in mice and partly also in humans. The host inflammasome is regulated by GBPs in response to bacterial infection in murine cells and may also respond to Toxoplasma infection. Elucidation of murine Toxoplasma defense mechanisms are guiding studies on human cells, while inevitably leading to the discovery of human-specific pathways that often function in a cell type-dependent manner.

Original languageEnglish (US)
Pages (from-to)72-80
Number of pages9
JournalCurrent Opinion in Microbiology
Volume40
DOIs
StatePublished - Dec 1 2017

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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