Exploring the virome of diseased horses

Linlin Li, Federico Giannitti, Jason Low, Casey Keyes, Leila S. Ullmann, Xutao Deng, Monica R Aleman, Patricia Pesavento, Nicola Pusterla, Eric Delwart

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Metagenomics was used to characterize viral genomes in clinical specimens of horses with various organ-specific diseases of unknown aetiology. A novel parvovirus as well as a previously described hepacivirus closely related to human hepatitis C virus and equid herpesvirus 2 were identified in the cerebrospinal fluid of horses with neurological signs. Four co-infecting picobirnaviruses, including an unusual genome with fused RNA segments, and a divergent anellovirus were found in the plasma of two febrile horses. A novel cyclovirus genome was characterized from the nasal secretion of another febrile animal. Lastly, a small circular DNA genome with a Rep gene, from a virus we called kirkovirus, was identified in the liver and spleen of a horse with fatal idiopathic hepatopathy. This study expands the number of viruses found in horses, and characterizes their genomes to assist future epidemiological studies of their transmission and potential association with various equine diseases.

Original languageEnglish (US)
Pages (from-to)2721-2733
Number of pages13
JournalJournal of General Virology
Volume96
Issue number9
DOIs
StatePublished - Sep 1 2015

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Horse Diseases
Horses
Genome
Hepacivirus
Anelloviridae
Picobirnavirus
Fever
Rhadinovirus
Viruses
Circular DNA
Metagenomics
Parvovirus
Viral Genome
Nose
Cerebrospinal Fluid
Epidemiologic Studies
Spleen
RNA
Liver
Genes

ASJC Scopus subject areas

  • Virology

Cite this

Li, L., Giannitti, F., Low, J., Keyes, C., Ullmann, L. S., Deng, X., ... Delwart, E. (2015). Exploring the virome of diseased horses. Journal of General Virology, 96(9), 2721-2733. https://doi.org/10.1099/vir.0.000199

Exploring the virome of diseased horses. / Li, Linlin; Giannitti, Federico; Low, Jason; Keyes, Casey; Ullmann, Leila S.; Deng, Xutao; Aleman, Monica R; Pesavento, Patricia; Pusterla, Nicola; Delwart, Eric.

In: Journal of General Virology, Vol. 96, No. 9, 01.09.2015, p. 2721-2733.

Research output: Contribution to journalArticle

Li, L, Giannitti, F, Low, J, Keyes, C, Ullmann, LS, Deng, X, Aleman, MR, Pesavento, P, Pusterla, N & Delwart, E 2015, 'Exploring the virome of diseased horses', Journal of General Virology, vol. 96, no. 9, pp. 2721-2733. https://doi.org/10.1099/vir.0.000199
Li L, Giannitti F, Low J, Keyes C, Ullmann LS, Deng X et al. Exploring the virome of diseased horses. Journal of General Virology. 2015 Sep 1;96(9):2721-2733. https://doi.org/10.1099/vir.0.000199
Li, Linlin ; Giannitti, Federico ; Low, Jason ; Keyes, Casey ; Ullmann, Leila S. ; Deng, Xutao ; Aleman, Monica R ; Pesavento, Patricia ; Pusterla, Nicola ; Delwart, Eric. / Exploring the virome of diseased horses. In: Journal of General Virology. 2015 ; Vol. 96, No. 9. pp. 2721-2733.
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