@article{adebf85f549c4c2ca0bfd8012ca8eca0,
title = "Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique",
abstract = "The patch clamp technique underwent continual advancement and developed numerous variants in cardiac electrophysiology since its introduction in the late 1970s. In the beginning, the capability of the technique was limited to recording one single current from one cell stimulated with a rectangular command pulse. Since that time, the technique has been extended to record multiple currents under various command pulses including action potential. The current review summarizes the development of the patch clamp technique in cardiac electrophysiology with special focus on the potential applications in integrative physiology.",
keywords = "action potential voltage clamp, cardiac electrophysiology, ion current, pharmacology, voltage clamp",
author = "Bal{\'a}zs Horv{\'a}th and Norbert Szentandr{\'a}ssy and Csaba Dienes and Kov{\'a}cs, {Zsigmond M.} and N{\'a}n{\'a}si, {P{\'e}ter P.} and Ye Chen-Izu and Izu, {Leighton T.} and Tamas Banyasz",
note = "Funding Information: This work was funded by the UD Faculty of Medicine Bridging Found to TB and the National Research Development and Innovation Office (NKFIH-K115397 to PN and NS; NKFIH-K138090 to CD, PN, and NS; and NKFIH-FK128116 to BH). Further support was provided by GINOP-2.3.2-15-2016-00040 and EFOP-3.6.2-16-2017-00006 (to PN), which are co-financed by the European Union and the European Regional Development Fund. Support was also obtained from the Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary (TKP-2020-NKA-04) within the framework of the Space Sciences thematic program of the University of Debrecen. CD was supported by the EFOP-3.6.3-VEKOP-16-2017-00009 project co-financed by the EU and the European Social Fund and by the {\'U}NKP-21-3 New National Excellence Program of the Ministry for Innovation and Technology from the National Research Development and Innovation Fund. Funding sources had no involvement in the preparation of the article; in the study design; in the collection, analysis, and interpretation of data; in writing of the report; or in the decision to submit the article for publication. Funding Information: This work was funded by the UD Faculty of Medicine Bridging Found to TB and the National Research Development and Innovation Office (NKFIH-K115397 to PN and NS; NKFIH-K138090 to CD, PN, and NS; and NKFIH-FK128116 to BH). Further support was provided by GINOP-2.3.2-15-2016-00040 and EFOP-3.6.2-16-2017-00006 (to PN), which are co-financed by the European Union and the European Regional Development Fund. Support was also obtained from the Thematic Excellence Program of the Ministry for Innovation and Technology in Hungary (TKP-2020-NKA-04) within the framework of the Space Sciences thematic program of the University of Debrecen. CD was supported by the EFOP-3.6.3-VEKOP-16-2017-00009 project co-financed by the EU and the European Social Fund and by the ?NKP-21-3 New National Excellence Program of the Ministry for Innovation and Technology from the National Research Development and Innovation Fund. Funding sources had no involvement in the preparation of the article; in the study design; in the collection, analysis, and interpretation of data; in writing of the report; or in the decision to submit the article for publication. Publisher Copyright: Copyright {\textcopyright} 2022 Horv{\'a}th, Szentandr{\'a}ssy, Dienes, Kov{\'a}cs, N{\'a}n{\'a}si, Chen-Izu, Izu and Banyasz.",
year = "2022",
month = mar,
day = "16",
doi = "10.3389/fphys.2022.864002",
language = "English (US)",
volume = "13",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",
}