Exploring predictors of outcome in the psychosis prodrome: Implications for early identification and intervention

Tara A Niendam, Maria Jalbrzikowski, Carrie E. Bearden

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Functional disability is a key component of many psychiatric illnesses, particularly schizophrenia. Impairments in social and role functioning are linked to cognitive deficits, a core feature of psychosis. Retrospective analyses demonstrate that substantial functional decline precedes the onset of psychosis. Recent investigations reveal that individuals at clinical-high-risk (CHR) for psychosis show impairments in social relationships, work/school functioning and daily living skills. CHR youth also demonstrate a pattern of impairment across a range of cognitive domains, including social cognition, which is qualitatively similar to that of individuals with schizophrenia. While many studies have sought to elucidate predictors of clinical deterioration, specifically the development of schizophrenia, in such CHR samples, few have investigated factors relevant to psychosocial outcome. This review integrates recent findings regarding cognitive and social-cognitive predictors of outcome in CHR individuals, and proposes potential directions for future research that will contribute to targeted interventions and improved outcome for at-risk youth.

Original languageEnglish (US)
Pages (from-to)280-293
Number of pages14
JournalNeuropsychology Review
Issue number3
StatePublished - 2009


  • Clinical high-risk
  • Functional outcome
  • Neurocognition
  • Prodrome
  • Psychosocial functioning
  • Schizophrenia
  • Social cognition
  • Ultra-high-risk

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology


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