Exploiting the natural history of cytomegalovirus to vaccinate against HIV

Ellen E. Sparger, Murray B. Gardner, Peter A Barry

Research output: Contribution to journalArticle

Abstract

The quest for a HIV vaccine that prevents HIV infection remains an ongoing struggle after failures of candidate vaccines in clinical trials. The threshold for a HIV vaccine is enormous. Vaccinestimulated immunity must restrict HIV replication to the mucosal surface and prevent any systemic spread. A recent study at the Oregon National Primate Research Center (OR, USA) involving the SIV/rhesus macaque model of HIV demonstrates that it is possible to elicit protective immunity to repeated rectal exposure of virulent SIV. Together with other rhesus macaque studies, the results offer a paradigm for vaccine protection against the sexual transmission of HIV.

Original languageEnglish (US)
Pages (from-to)993-997
Number of pages5
JournalExpert Review of Vaccines
Volume8
Issue number8
DOIs
StatePublished - Aug 2009

Keywords

  • HIV
  • HIV vaccine
  • Rhesus cytomegalovirus
  • Rhesus macaque
  • Sexual transmission of HIV
  • SIV

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

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