Exploiting the natural history of cytomegalovirus to vaccinate against HIV

Ellen E. Sparger; Murray B. Gardner; Peter A Barry

doi:10.1586/erv.09.70

Exploiting the natural history of cytomegalovirus to vaccinate against HIV

Ellen E. Sparger, Murray B. Gardner, Peter A Barry

Research output: Contribution to journal › Article › peer-review

Abstract

The quest for a HIV vaccine that prevents HIV infection remains an ongoing struggle after failures of candidate vaccines in clinical trials. The threshold for a HIV vaccine is enormous. Vaccinestimulated immunity must restrict HIV replication to the mucosal surface and prevent any systemic spread. A recent study at the Oregon National Primate Research Center (OR, USA) involving the SIV/rhesus macaque model of HIV demonstrates that it is possible to elicit protective immunity to repeated rectal exposure of virulent SIV. Together with other rhesus macaque studies, the results offer a paradigm for vaccine protection against the sexual transmission of HIV.

Original language	English (US)
Pages (from-to)	993-997
Number of pages	5
Journal	Expert Review of Vaccines
Volume	8
Issue number	8
DOIs	https://doi.org/10.1586/erv.09.70
State	Published - Aug 2009

Keywords

HIV
HIV vaccine
Rhesus cytomegalovirus
Rhesus macaque
Sexual transmission of HIV
SIV

ASJC Scopus subject areas

Immunology
Drug Discovery
Pharmacology
Molecular Medicine

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