Abstract
The quest for a HIV vaccine that prevents HIV infection remains an ongoing struggle after failures of candidate vaccines in clinical trials. The threshold for a HIV vaccine is enormous. Vaccinestimulated immunity must restrict HIV replication to the mucosal surface and prevent any systemic spread. A recent study at the Oregon National Primate Research Center (OR, USA) involving the SIV/rhesus macaque model of HIV demonstrates that it is possible to elicit protective immunity to repeated rectal exposure of virulent SIV. Together with other rhesus macaque studies, the results offer a paradigm for vaccine protection against the sexual transmission of HIV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 993-997 |
| Number of pages | 5 |
| Journal | Expert Review of Vaccines |
| Volume | 8 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2009 |
Keywords
- HIV
- HIV vaccine
- Rhesus cytomegalovirus
- Rhesus macaque
- Sexual transmission of HIV
- SIV
ASJC Scopus subject areas
- Immunology
- Drug Discovery
- Pharmacology
- Molecular Medicine
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Cite this
Sparger, E. E., Gardner, M. B., & Barry, P. A. (2009). Exploiting the natural history of cytomegalovirus to vaccinate against HIV. Expert Review of Vaccines, 8(8), 993-997. https://doi.org/10.1586/erv.09.70