Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer

Akhil Srivastava, Anish Babu, Justyna Filant, Katherine M. Moxley, Rachel Ruskin, Danny Dhanasekaran, Anil K. Sood, Scott McMeekin, Rajagopal Ramesh

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The bottleneck in current vector-based cancer therapy is the targeted and controlled release of therapeutics in tumors. Exosomes are submicron-sized vesicles that are secreted by all cell types and are involved in communication and transportation of materials between cells. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Patient-specific customized therapeutic strategies can be engineered using exosomes derived from the patient's own healthy cells. Therefore, exosome-based cancer therapy has the potential to become an important part of personalized medicine. Interest in exosomes as carrier organelles is relatively recent. Knowledge about exosomal biology and its applications remains limited. The present review is an attempt to describe the current status of the application of exosomes to cancer therapy and the potential challenges associated with their use.

Original languageEnglish (US)
Pages (from-to)1159-1173
Number of pages15
JournalJournal of Biomedical Nanotechnology
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Exosomes
Genes
Bioelectric potentials
Medicine
Tumors
Neoplasms
Cells
Nanoparticles
Communication
Therapeutics
Pharmaceutical Preparations
Precision Medicine
Organelles

Keywords

  • Cancer
  • Drug delivery
  • Exosomes
  • Extracellular vesicles
  • Metastasis
  • MiRNA
  • Nanoparticles
  • Tumor microenvironment

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Srivastava, A., Babu, A., Filant, J., Moxley, K. M., Ruskin, R., Dhanasekaran, D., ... Ramesh, R. (2016). Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer. Journal of Biomedical Nanotechnology, 12(6), 1159-1173. https://doi.org/10.1166/jbn.2016.2205

Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer. / Srivastava, Akhil; Babu, Anish; Filant, Justyna; Moxley, Katherine M.; Ruskin, Rachel; Dhanasekaran, Danny; Sood, Anil K.; McMeekin, Scott; Ramesh, Rajagopal.

In: Journal of Biomedical Nanotechnology, Vol. 12, No. 6, 01.06.2016, p. 1159-1173.

Research output: Contribution to journalArticle

Srivastava, A, Babu, A, Filant, J, Moxley, KM, Ruskin, R, Dhanasekaran, D, Sood, AK, McMeekin, S & Ramesh, R 2016, 'Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer', Journal of Biomedical Nanotechnology, vol. 12, no. 6, pp. 1159-1173. https://doi.org/10.1166/jbn.2016.2205
Srivastava, Akhil ; Babu, Anish ; Filant, Justyna ; Moxley, Katherine M. ; Ruskin, Rachel ; Dhanasekaran, Danny ; Sood, Anil K. ; McMeekin, Scott ; Ramesh, Rajagopal. / Exploitation of exosomes as nanocarriers for gene-, chemo-, and immune-therapy of cancer. In: Journal of Biomedical Nanotechnology. 2016 ; Vol. 12, No. 6. pp. 1159-1173.
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