Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease

Christine G. Parks, Frederick W. Miller, Kenneth M ichael Pollard, Carlo Selmi, Dori Germolec, Kelly Joyce, Noel R. Rose, Michael C. Humble

Research output: Contribution to journalArticle

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Abstract

Autoimmune diseases include 80 or more complex disorders characterized by self-reactive, pathologic immune responses in which genetic susceptibility is largely insufficient to determine disease onset. In September 2010, the National Institute of Environmental Health Sciences (NIEHS) organized an expert panel workshop to evaluate the role of environmental factors in autoimmune diseases, and the state of the science regarding relevant mechanisms, animal models, and human studies. The objective of the workshop was to analyze the existing data to identify conclusions that could be drawn regarding environmental exposures and autoimmunity and to identify critical knowledge gaps and areas of uncertainty for future study. This consensus document summarizes key findings from published workshop monographs on areas in which "confident" and "likely" assessments were made, with recommendations for further research. Transcribed notes and slides were reviewed to synthesize an overview on exposure assessment and questions addressed by interdisciplinary panels. Critical advances in the field of autoimmune disease research have been made in the past decade. Collaborative translational and interdisciplinary research is needed to elucidate the role of environmental factors in autoimmune diseases. A focus on exposure assessment methodology is needed to improve the effectiveness of human studies, and more experimental studies are needed to focus on causal mechanisms underlying observed associations of environmental factors with autoimmune disease in humans.

Original languageEnglish (US)
Pages (from-to)14269-14297
Number of pages29
JournalInternational Journal of Molecular Sciences
Volume15
Issue number8
DOIs
StatePublished - 2014

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Consensus Development Conferences
Autoimmune Diseases
Education
National Institute of Environmental Health Sciences (U.S.)
Translational Medical Research
Environmental Exposure
Genetic Predisposition to Disease
animal models
Autoimmunity
Research
Uncertainty
chutes
recommendations
Animal Models
health
Animals
Health
disorders
methodology
magnetic permeability

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Parks, C. G., Miller, F. W., Pollard, K. M. I., Selmi, C., Germolec, D., Joyce, K., ... Humble, M. C. (2014). Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease. International Journal of Molecular Sciences, 15(8), 14269-14297. https://doi.org/10.3390/ijms150814269

Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease. / Parks, Christine G.; Miller, Frederick W.; Pollard, Kenneth M ichael; Selmi, Carlo; Germolec, Dori; Joyce, Kelly; Rose, Noel R.; Humble, Michael C.

In: International Journal of Molecular Sciences, Vol. 15, No. 8, 2014, p. 14269-14297.

Research output: Contribution to journalArticle

Parks, CG, Miller, FW, Pollard, KMI, Selmi, C, Germolec, D, Joyce, K, Rose, NR & Humble, MC 2014, 'Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease', International Journal of Molecular Sciences, vol. 15, no. 8, pp. 14269-14297. https://doi.org/10.3390/ijms150814269
Parks, Christine G. ; Miller, Frederick W. ; Pollard, Kenneth M ichael ; Selmi, Carlo ; Germolec, Dori ; Joyce, Kelly ; Rose, Noel R. ; Humble, Michael C. / Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease. In: International Journal of Molecular Sciences. 2014 ; Vol. 15, No. 8. pp. 14269-14297.
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