Experiments from unfinished registered reports in the reproducibility project: Cancer biology

Timothy M. Errington, Alexandria Denis, Anne B. Allison, Renee Araiza, Pedro Aza-Blanc, Lynette R. Bower, Jessica Campos, Heidi Chu, Sarah Denson, Cristine Donham, Kaitlyn Harr, Babette Haven, Elizabeth Iorns, Jennie Kwok, Elysia McDonald, Steven Pelech, Nicole Perfito, Amanda Pike, Darryl Sampey, Michael SettlesDavid A. Scott, Vidhu Sharma, Todd Tolentino, Angela Trinh, Rachel Tsui, Brandon Willis, Joshua Wood, Lisa Young

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

As part of the Reproducibility Project: Cancer Biology, we published Registered Reports that described how we intended to replicate selected experiments from 29 high-impact preclinical cancer biology papers published between 2010 and 2012. Replication experiments were completed and Replication Studies reporting the results were submitted for 18 papers, of which 17 were accepted and published by eLife with the rejected paper posted as a preprint. Here, we report the status and outcomes obtained for the remaining 11 papers. Four papers initiated experimental work but were stopped without any experimental outcomes. Two papers resulted in incomplete outcomes due to unanticipated challenges when conducting the exper-iments. For the remaining five papers only some of the experiments were completed with the other experiments incomplete due to mundane technical or unanticipated methodological challenges. The experiments from these papers, along with the other experiments attempted as part of the Reproducibility Project: Cancer Biology, provides evidence about the challenges of repeating preclinical cancer biology experiments and the replicability of the completed experiments.

Original languageEnglish (US)
Article numbere73430
JournaleLife
Volume10
DOIs
StatePublished - Dec 2021

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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