Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF, thromboxane B2, and acid-base parameters

Roseanne M. Lorenzana, Val R. Beasley, William B. Buck, Arthur W. Ghent, Gregg R. Lundeen, Robert H Poppenga

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

Original languageEnglish (US)
Pages (from-to)879-892
Number of pages14
JournalFundamental and Applied Toxicology
Volume5
Issue number5
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology

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