Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1α, thromboxane B2, and acid-base parameters

Roseanne M. Lorenzana; Val R. Beasley; William B. Buck; Arthur W. Ghent; Gregg R. Lundeen; Robert H Poppenga

doi:10.1016/0272-0590(85)90170-8

Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF_1α, thromboxane B₂, and acid-base parameters

Roseanne M. Lorenzana, Val R. Beasley, William B. Buck, Arthur W. Ghent, Gregg R. Lundeen, Robert H Poppenga

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B₂, 6-keto PGF_1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

Original language	English (US)
Pages (from-to)	879-892
Number of pages	14
Journal	Fundamental and Applied Toxicology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/0272-0590(85)90170-8
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF_1α, thromboxane B₂, and acid-base parameters. / Lorenzana, Roseanne M.; Beasley, Val R.; Buck, William B.; Ghent, Arthur W.; Lundeen, Gregg R.; Poppenga, Robert H.

In: Fundamental and Applied Toxicology, Vol. 5, No. 5, 1985, p. 879-892.

Research output: Contribution to journal › Article › peer-review

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abstract = "T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.",

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AU - Lorenzana, Roseanne M.

AU - Beasley, Val R.

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AU - Ghent, Arthur W.

AU - Lundeen, Gregg R.

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AB - T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

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