Abstract
T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 879-892 |
| Number of pages | 14 |
| Journal | Fundamental and Applied Toxicology |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Toxicology
Cite this
Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1α, thromboxane B2, and acid-base parameters. / Lorenzana, Roseanne M.; Beasley, Val R.; Buck, William B.; Ghent, Arthur W.; Lundeen, Gregg R.; Poppenga, Robert H.
In: Fundamental and Applied Toxicology, Vol. 5, No. 5, 1985, p. 879-892.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1α, thromboxane B2, and acid-base parameters
AU - Lorenzana, Roseanne M.
AU - Beasley, Val R.
AU - Buck, William B.
AU - Ghent, Arthur W.
AU - Lundeen, Gregg R.
AU - Poppenga, Robert H
PY - 1985
Y1 - 1985
N2 - T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.
AB - T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.
UR - http://www.scopus.com/inward/record.url?scp=0022341463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022341463&partnerID=8YFLogxK
U2 - 10.1016/0272-0590(85)90170-8
DO - 10.1016/0272-0590(85)90170-8
M3 - Article
C2 - 3840756
AN - SCOPUS:0022341463
VL - 5
SP - 879
EP - 892
JO - Toxicological Sciences
JF - Toxicological Sciences
SN - 1096-6080
IS - 5
ER -