Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF, thromboxane B2, and acid-base parameters

Roseanne M. Lorenzana, Val R. Beasley, William B. Buck, Arthur W. Ghent, Gregg R. Lundeen, Robert H Poppenga

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

Original languageEnglish (US)
Pages (from-to)879-892
Number of pages14
JournalFundamental and Applied Toxicology
Volume5
Issue number5
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Thromboxane B2
Cardiac Output
Vascular Resistance
Catecholamines
Shock
Arterial Pressure
Swine
T-2 Toxin
Plasmas
Acids
Partial Pressure
Blood pressure
Partial pressure
Histamine
Epinephrine
Lactic Acid
Serotonin
Norepinephrine
Oxygen
Blood Pressure

ASJC Scopus subject areas

  • Toxicology

Cite this

Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF, thromboxane B2, and acid-base parameters. / Lorenzana, Roseanne M.; Beasley, Val R.; Buck, William B.; Ghent, Arthur W.; Lundeen, Gregg R.; Poppenga, Robert H.

In: Fundamental and Applied Toxicology, Vol. 5, No. 5, 1985, p. 879-892.

Research output: Contribution to journalArticle

Lorenzana, Roseanne M. ; Beasley, Val R. ; Buck, William B. ; Ghent, Arthur W. ; Lundeen, Gregg R. ; Poppenga, Robert H. / Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF, thromboxane B2, and acid-base parameters. In: Fundamental and Applied Toxicology. 1985 ; Vol. 5, No. 5. pp. 879-892.
@article{b9a0fefeb496447ab60ccbac78d3a061,
title = "Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1α, thromboxane B2, and acid-base parameters",
abstract = "T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.",
author = "Lorenzana, {Roseanne M.} and Beasley, {Val R.} and Buck, {William B.} and Ghent, {Arthur W.} and Lundeen, {Gregg R.} and Poppenga, {Robert H}",
year = "1985",
doi = "10.1016/0272-0590(85)90170-8",
language = "English (US)",
volume = "5",
pages = "879--892",
journal = "Toxicological Sciences",
issn = "1096-6080",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1α, thromboxane B2, and acid-base parameters

AU - Lorenzana, Roseanne M.

AU - Beasley, Val R.

AU - Buck, William B.

AU - Ghent, Arthur W.

AU - Lundeen, Gregg R.

AU - Poppenga, Robert H

PY - 1985

Y1 - 1985

N2 - T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

AB - T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

UR - http://www.scopus.com/inward/record.url?scp=0022341463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022341463&partnerID=8YFLogxK

U2 - 10.1016/0272-0590(85)90170-8

DO - 10.1016/0272-0590(85)90170-8

M3 - Article

C2 - 3840756

AN - SCOPUS:0022341463

VL - 5

SP - 879

EP - 892

JO - Toxicological Sciences

JF - Toxicological Sciences

SN - 1096-6080

IS - 5

ER -