Experimental T-2 toxicosis in swine

I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-pgf, thromboxane b2, and acid-base parameters

Roseanne M. Lorenzana, Val R. Beasley, William B. Buck, Arthur W. Ghent, Gregg R. Lundeen, Robert H Poppenga

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Experimental T-2 Toxicosis in Swine. I. Changes in Cardiac Output, Aortic Mean Pressure, Catecholamines, 6-Keto-PGF, Thromboxane B2, and Acid-Base Parameters. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., GHENT, A. W., LUNDEEN, G. R., AND POPPENGA, R. H. (1985). Fundam. Appl. Toxicol.. 5,879-892. T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.

Original languageEnglish (US)
Pages (from-to)879-892
Number of pages14
JournalToxicological Sciences
Volume5
Issue number5
DOIs
StatePublished - Oct 1985
Externally publishedYes

Fingerprint

Thromboxane B2
Cardiac Output
Catecholamines
Arterial Pressure
Swine
T-2 Toxin
Plasmas
Vascular Resistance
Acids
Shock
Blood pressure
Partial pressure
Histamine
Epinephrine
Lactic Acid
Serotonin
Norepinephrine
Partial Pressure
Oxygen
Blood Pressure

ASJC Scopus subject areas

  • Molecular Biology
  • Embryology
  • Cell Biology
  • Genetics
  • Developmental Biology
  • Toxicology

Cite this

Experimental T-2 toxicosis in swine : I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-pgf, thromboxane b2, and acid-base parameters. / Lorenzana, Roseanne M.; Beasley, Val R.; Buck, William B.; Ghent, Arthur W.; Lundeen, Gregg R.; Poppenga, Robert H.

In: Toxicological Sciences, Vol. 5, No. 5, 10.1985, p. 879-892.

Research output: Contribution to journalArticle

Lorenzana, Roseanne M. ; Beasley, Val R. ; Buck, William B. ; Ghent, Arthur W. ; Lundeen, Gregg R. ; Poppenga, Robert H. / Experimental T-2 toxicosis in swine : I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-pgf, thromboxane b2, and acid-base parameters. In: Toxicological Sciences. 1985 ; Vol. 5, No. 5. pp. 879-892.
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abstract = "Experimental T-2 Toxicosis in Swine. I. Changes in Cardiac Output, Aortic Mean Pressure, Catecholamines, 6-Keto-PGF1α, Thromboxane B2, and Acid-Base Parameters. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., GHENT, A. W., LUNDEEN, G. R., AND POPPENGA, R. H. (1985). Fundam. Appl. Toxicol.. 5,879-892. T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.",
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