Experimental reproduction of severe bluetongue in sheep

Nigel J Maclachlan, J. E. Crafford, William Vernau, Ian Gardner, A. Goddard, A. J. Guthrie, E. H. Venter

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalVeterinary Pathology
Volume45
Issue number3
DOIs
StatePublished - May 2008

Fingerprint

Bluetongue
bluetongue
Reproduction
Sheep
sheep
edema
neck
hemorrhage
African Horse Sickness
Neck
African horse sickness
Bluetongue virus
Hemorrhage
pericardial effusion
forestomach
Pericardial Effusion
pulmonary artery
Subcutaneous Tissue
Capillary Permeability
Pulmonary Edema

Keywords

  • African horse sickness
  • Bluetongue
  • Pathogenesis
  • Sheep

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Experimental reproduction of severe bluetongue in sheep. / Maclachlan, Nigel J; Crafford, J. E.; Vernau, William; Gardner, Ian; Goddard, A.; Guthrie, A. J.; Venter, E. H.

In: Veterinary Pathology, Vol. 45, No. 3, 05.2008, p. 310-315.

Research output: Contribution to journalArticle

Maclachlan, Nigel J ; Crafford, J. E. ; Vernau, William ; Gardner, Ian ; Goddard, A. ; Guthrie, A. J. ; Venter, E. H. / Experimental reproduction of severe bluetongue in sheep. In: Veterinary Pathology. 2008 ; Vol. 45, No. 3. pp. 310-315.
@article{b639933fdf76408794bfe3f3022a1aec,
title = "Experimental reproduction of severe bluetongue in sheep",
abstract = "Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.",
keywords = "African horse sickness, Bluetongue, Pathogenesis, Sheep",
author = "Maclachlan, {Nigel J} and Crafford, {J. E.} and William Vernau and Ian Gardner and A. Goddard and Guthrie, {A. J.} and Venter, {E. H.}",
year = "2008",
month = "5",
doi = "10.1354/vp.45-3-310",
language = "English (US)",
volume = "45",
pages = "310--315",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Experimental reproduction of severe bluetongue in sheep

AU - Maclachlan, Nigel J

AU - Crafford, J. E.

AU - Vernau, William

AU - Gardner, Ian

AU - Goddard, A.

AU - Guthrie, A. J.

AU - Venter, E. H.

PY - 2008/5

Y1 - 2008/5

N2 - Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.

AB - Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.

KW - African horse sickness

KW - Bluetongue

KW - Pathogenesis

KW - Sheep

UR - http://www.scopus.com/inward/record.url?scp=50949114188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50949114188&partnerID=8YFLogxK

U2 - 10.1354/vp.45-3-310

DO - 10.1354/vp.45-3-310

M3 - Article

VL - 45

SP - 310

EP - 315

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 3

ER -