Abstract
Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 310-315 |
| Number of pages | 6 |
| Journal | Veterinary Pathology |
| Volume | 45 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2008 |
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Keywords
- African horse sickness
- Bluetongue
- Pathogenesis
- Sheep
ASJC Scopus subject areas
- veterinary(all)
Cite this
Experimental reproduction of severe bluetongue in sheep. / Maclachlan, Nigel J; Crafford, J. E.; Vernau, William; Gardner, Ian; Goddard, A.; Guthrie, A. J.; Venter, E. H.
In: Veterinary Pathology, Vol. 45, No. 3, 05.2008, p. 310-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental reproduction of severe bluetongue in sheep
AU - Maclachlan, Nigel J
AU - Crafford, J. E.
AU - Vernau, William
AU - Gardner, Ian
AU - Goddard, A.
AU - Guthrie, A. J.
AU - Venter, E. H.
PY - 2008/5
Y1 - 2008/5
N2 - Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.
AB - Sheep inoculated with a virulent South African strain of bluetongue (BT) virus serotype 4 developed severe clinical signs and lesions characteristic of fulminant BT, including coronitis, hemorrhage and ulceration of the mucosal lining of the oral cavity and forestomaches, hemorrhage in the wall of the pulmonary artery, and focally extensive necrosis of skeletal muscle, especially of the neck. At necropsy, up to 14 days after infection, the infected sheep exhibited striking pulmonary edema, edema of the subcutaneous tissues and fascial planes of the head and neck, and pleural and pericardial effusion of varying severity. A reliable model for experimental reproduction of fulminant BT in sheep will facilitate future studies to better characterize the pathogenesis of this disease, particularly as it regards the mechanisms responsible for the increased vascular permeability that characterizes BT and related orbiviral diseases such as African horse sickness.
KW - African horse sickness
KW - Bluetongue
KW - Pathogenesis
KW - Sheep
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UR - http://www.scopus.com/inward/citedby.url?scp=50949114188&partnerID=8YFLogxK
U2 - 10.1354/vp.45-3-310
DO - 10.1354/vp.45-3-310
M3 - Article
VL - 45
SP - 310
EP - 315
JO - Veterinary Pathology
JF - Veterinary Pathology
SN - 0300-9858
IS - 3
ER -