Experimental models of B cell tolerance in transplantation

Michelle L. Cowan, Roger Sciammas, Anita S. Chong

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The use of conventional immunosuppression has successfully improved short-term allograft survival, however, long-term allograft survival has remained static and is complicated by serious side effects secondary to the long-term use of immunosuppressive agents. Immunological tolerance is the ultimate goal of organ transplantation, however it is an infrequent event in humans. Accordingly, over the past several decades, there has been a push to fully understand both the cellular and molecular mechanisms that play a role in the induction and maintenance of tolerance, with recent data implicating B cells and donor specific alloantibody as a barrier to and potential mediator of allograft tolerance. The study of B cells and alloantibody in transplant tolerance has evolved over recent years from using rodent models to non-human primate models. This review will discuss the role of B cells and alloantibody as antagonists and facilitators of transplantation tolerance, and highlight the experimental models developed for elucidating the mechanisms of B cell tolerance to alloantigen.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalSeminars in Immunology
Volume24
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Transplantation Tolerance
Isoantibodies
B-Lymphocytes
Theoretical Models
Allografts
Isoantigens
Organ Transplantation
Immunosuppressive Agents
Immunosuppression
Primates
Rodentia
Maintenance
Transplants

Keywords

  • Antibodies
  • B cells
  • Experimental models
  • Transplantation tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Experimental models of B cell tolerance in transplantation. / Cowan, Michelle L.; Sciammas, Roger; Chong, Anita S.

In: Seminars in Immunology, Vol. 24, No. 2, 04.2012, p. 77-85.

Research output: Contribution to journalReview article

Cowan, Michelle L. ; Sciammas, Roger ; Chong, Anita S. / Experimental models of B cell tolerance in transplantation. In: Seminars in Immunology. 2012 ; Vol. 24, No. 2. pp. 77-85.
@article{f523af6334264f96b723cc414d715772,
title = "Experimental models of B cell tolerance in transplantation",
abstract = "The use of conventional immunosuppression has successfully improved short-term allograft survival, however, long-term allograft survival has remained static and is complicated by serious side effects secondary to the long-term use of immunosuppressive agents. Immunological tolerance is the ultimate goal of organ transplantation, however it is an infrequent event in humans. Accordingly, over the past several decades, there has been a push to fully understand both the cellular and molecular mechanisms that play a role in the induction and maintenance of tolerance, with recent data implicating B cells and donor specific alloantibody as a barrier to and potential mediator of allograft tolerance. The study of B cells and alloantibody in transplant tolerance has evolved over recent years from using rodent models to non-human primate models. This review will discuss the role of B cells and alloantibody as antagonists and facilitators of transplantation tolerance, and highlight the experimental models developed for elucidating the mechanisms of B cell tolerance to alloantigen.",
keywords = "Antibodies, B cells, Experimental models, Transplantation tolerance",
author = "Cowan, {Michelle L.} and Roger Sciammas and Chong, {Anita S.}",
year = "2012",
month = "4",
doi = "10.1016/j.smim.2011.08.018",
language = "English (US)",
volume = "24",
pages = "77--85",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Experimental models of B cell tolerance in transplantation

AU - Cowan, Michelle L.

AU - Sciammas, Roger

AU - Chong, Anita S.

PY - 2012/4

Y1 - 2012/4

N2 - The use of conventional immunosuppression has successfully improved short-term allograft survival, however, long-term allograft survival has remained static and is complicated by serious side effects secondary to the long-term use of immunosuppressive agents. Immunological tolerance is the ultimate goal of organ transplantation, however it is an infrequent event in humans. Accordingly, over the past several decades, there has been a push to fully understand both the cellular and molecular mechanisms that play a role in the induction and maintenance of tolerance, with recent data implicating B cells and donor specific alloantibody as a barrier to and potential mediator of allograft tolerance. The study of B cells and alloantibody in transplant tolerance has evolved over recent years from using rodent models to non-human primate models. This review will discuss the role of B cells and alloantibody as antagonists and facilitators of transplantation tolerance, and highlight the experimental models developed for elucidating the mechanisms of B cell tolerance to alloantigen.

AB - The use of conventional immunosuppression has successfully improved short-term allograft survival, however, long-term allograft survival has remained static and is complicated by serious side effects secondary to the long-term use of immunosuppressive agents. Immunological tolerance is the ultimate goal of organ transplantation, however it is an infrequent event in humans. Accordingly, over the past several decades, there has been a push to fully understand both the cellular and molecular mechanisms that play a role in the induction and maintenance of tolerance, with recent data implicating B cells and donor specific alloantibody as a barrier to and potential mediator of allograft tolerance. The study of B cells and alloantibody in transplant tolerance has evolved over recent years from using rodent models to non-human primate models. This review will discuss the role of B cells and alloantibody as antagonists and facilitators of transplantation tolerance, and highlight the experimental models developed for elucidating the mechanisms of B cell tolerance to alloantigen.

KW - Antibodies

KW - B cells

KW - Experimental models

KW - Transplantation tolerance

UR - http://www.scopus.com/inward/record.url?scp=84859264325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859264325&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2011.08.018

DO - 10.1016/j.smim.2011.08.018

M3 - Review article

C2 - 21925896

AN - SCOPUS:84859264325

VL - 24

SP - 77

EP - 85

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 2

ER -