Abstract
Schwann cells were prepared from the sciatic nerves of newborn rats and cultured in a monolayer. Addition of lead acetate at concentrations between 0.4 and 10.0 μg/ml, levels comparable to those occurring in neural tissues and physiological fluids of lead-intoxicated rats, diminished both the baseline rate of proliferation of the Schwann cells and their response to the mitogens, axolemmal fragments, glial growth factor, and the adenosine 3':5'-cyclic monophosphate (cAMP) analogues 8-bromo-cAMP and dibutyryl-cAMP. This demonstrates a direct toxic effect of inorganic lead on Schwann cells. Lead acetate in this concentration range did not, however, inhibit the cAMP analogue-induced appearance of the 'myelin marker' lipid galactocerebroside on the surfaces of the cultured Schwann cells.
Original language | English (US) |
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Pages (from-to) | 462-468 |
Number of pages | 7 |
Journal | Annals of Neurology |
Volume | 17 |
Issue number | 5 |
State | Published - 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)