Experimental internuclear ophthalmoplegia

R. M. Burde, R. A W Lehman, G. Roper Hall, J. Brooks, J. L. Keltner

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A midline experimental lesion separating the medial longitudinal fasciculi at and below the level of the abducens nuclei without damaging either fasciculus at the level of the nuclei has produced defects of ocular motility resembling those of clinical internuclear ophthalmoplegia. Electromyographic recordings during lateral gaze demonstrate: lack of inhibition of the lateral rectus muscle in the adducting eye, delayed inhibition of the medial rectus muscle in the abducting eye, and occasional evidence of excitation of the medial rectus muscle of the abducting eye probably associated with pupillary constriction. The presumed physiologic mechanisms involved in conjugate gaze movements are discussed in the light of the experimental findings.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalBritish Journal of Ophthalmology
Issue number3
StatePublished - 1977

ASJC Scopus subject areas

  • Ophthalmology


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