Experimental inoculation with human granulocytic ehrlichia agent derived from high- and low-passage cell culture in horses

Nicola Pusterla, John E Madigan, Kristin M. Asanovich, Joon Seok Chae, Elfriede Derock, Christian M. Leutenegger, Jeannine Berger Pusterla, Hans Lutz, J. Stephen Dumler

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We report the successful infection throughout intravenous inoculation with low and high passage of in vitro-grown human granulocytic ehrlichiosis (HGE) agent in horses. Differences in disease severity but not in incubation time, hematological changes, PCR detection, ehrlichial load, seroconversion time, and titer range were noted between horses infected with a low and a high passage of in vitro-grown HGE agent.

Original languageEnglish (US)
Pages (from-to)1276-1278
Number of pages3
JournalJournal of Clinical Microbiology
Volume38
Issue number3
StatePublished - Mar 2000

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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    Pusterla, N., Madigan, J. E., Asanovich, K. M., Chae, J. S., Derock, E., Leutenegger, C. M., Pusterla, J. B., Lutz, H., & Dumler, J. S. (2000). Experimental inoculation with human granulocytic ehrlichia agent derived from high- and low-passage cell culture in horses. Journal of Clinical Microbiology, 38(3), 1276-1278.